Dr. Sascha Wulff

- Provision of toxicological guidance, data, and assessments throughout the R&D project stages - Evaluate preclinical safety data, perform data gap analysis, derive reference doses (e.g., ADI, IOEL), and manage preclinical studies, including outsourcing, monitoring, and reporting - Preparation of safety assessments for registration dossiers, support Regulatory Affairs and various internal teams, and represent dsm-firmenich in meetings with regulatory authorities, scientific groups, and customers

- Ph.D. project "The Function of Retinol Saturase (RetSat) in Kidney" and contribution to other projects with organ-specific knockout models - strong hands-on experience in vivo (study design) and in vitro (gene editing methods) - communication with authorities - IT applications and responsible person for bioinformatic approaches - supervision/management of lab technicians and medical students - lecturer of medical students (Charité) for several years, teacher for a problem-based learning format

Master Thesis, title: "Understanding Toxicokinetic Processes in the Growing Zebrafish Embryo: Focus on Perfluorinated Compounds" - Fish Embryo Acute Toxicity Test (OECD Test No. 236) - contribute experimental data to new PBPK models in toxicokinetics - LC-MS/MS method development for quantification of perfluorinated compounds

− Synthesis of iron-based ferrofluids − Surface modification of ferromagnetic nanoparticles − Development of drug delivery systems for hydrophobic drugs

− Synthesis of iron-based ferrofluids − Surface modifcation of ferromagnetic nanoparticles − Layer-by-layer fabrication technique − Administrative activities in purchase, patents and account management

title: Deposition of Lambda-DNA in Polyelectrolyte Assemblies and Their Stability in Different Media − Screening of polyelectrolyte multilayer assemblies − Measurements of polyelectrolyte adsorption on planar surfaces with quartz crystal microbalance − Preparation of internal standard for qPCR