Dr. Dominik Barthelme
Angestellt, Director Protein Sciences, Ascendis Pharma GmbH
Heidelberg, Deutschland
Werdegang
Berufserfahrung von Dominik Barthelme
6 Monate, Juli 2019 - Dez. 2019
Associate Director, Biochemistry
Neon Therapeutics
1 Jahr und 6 Monate, Jan. 2018 - Juni 2019
Group Leader, Biochemistry
Neon Therapeutics
Build and managed biochemistry group (8 FTEs) and all protein sciences including protein engineering, cloning, expression and purification, development of cell-based and biochemical assays to support clinical immune monitoring and neoantigen-target discovery and leading the development of a next-generation cancer vaccine.
1 Jahr und 1 Monat, Jan. 2017 - Jan. 2018
Lab Head, Scientist II, Biochemistry
Neon Therapeutics
Build and managed biochemistry group (8 FTEs) and all protein sciences including protein engineering, cloning, expression and purification, development of cell-based and biochemical assays to support clinical immune monitoring and neoantigen-target discovery and leading the development of a next-generation cancer vaccine.
10 Monate, Apr. 2016 - Jan. 2017
Scientist I, Biochemistry
Neon Therapeutics
4 Monate, Jan. 2016 - Apr. 2016
Consultant, Biochemistry
Neon Therapeutics
9 Monate, Mai 2015 - Jan. 2016
Postdoctoral Research Fellow
Helmholz Zentrum für Infektionsforschung und MPI für Infektionsbiologie
Lab of Prof. Dr. Emmanuelle Charpentier Project: Identification and characterization of novel control mechanisms of host-pathogen interactions in the human pathogens Listeria monocytogenes.
4 Jahre und 2 Monate, Jan. 2011 - Feb. 2015
Postdoctoral Research Fellow
Massachusetts Institute of Technology
Lab of Prof. Dr. Robert T. Sauer Project: Biochemical and structural studies of protein homeostasis and protein degradation by the ubiquitin-proteasome system and the Cdc48/p97 AAA+ ATPase.
4 Jahre, Jan. 2007 - Dez. 2010
Graduate Student
Goethe-Universität Frankfurt am Main
Lab of Prof. Dr. Robert Tampé
4 Monate, Sep. 2006 - Dez. 2006
Research Intern
National Institute of Health/Bethesda (USA)
Lab of Prof. Dr. Alan G. Hinnebusch Project: Yeast genetic and cell biological studies on the metabolic regulation of mRNA translation.
1 Jahr, Nov. 2004 - Okt. 2005
Research Assistent
Goethe-Universität Frankfurt am Main
Lab of Prof. Dr. Julian C. Chen (concurrent with course work) Studied soluble chaperones and membrane transporters involved in copper homeostasis in E. coli; Optimized expression, solubilization and purification strategies for CusA, CusC and CusF.
1 Jahr, Aug. 2003 - Juli 2004
Research Assistant
Red Cross Blood Donor Service/ Institute of transfusion medicine
Lab of Prof. Dr. Thorsten Tonn (concurrent with course work) Assisted in the design and construction of new lentiviral expression vectors for the production of recombinant Factor VIII in human cell lines; Analyzed Factor VIII mRNA and protein expression by RT-PCR and western blotting; Cultivated human cell cultures
Ausbildung von Dominik Barthelme
4 Jahre, Jan. 2007 - Dez. 2010
Biochemie
Goethe-Universität Frankfurt am Main
Biochemistry, Molecular Biology, Biophysical Chemistry, Structural Biology
4 Jahre und 9 Monate, Okt. 2001 - Juni 2006
Biochemie
Goethe-Universität Frankfurt am Main
Biochemistry, Biophysical Chemistry, Cell Biology, Organic Chemistry
Sprachen
Deutsch
Muttersprache
Englisch
Fließend
Französisch
Grundlagen