Dr. Paola Stephanie Apaolaza Gallegos

Hyaluronic Acid coated-Gold Nanoparticles as Delivery Systems of Natriuretic Peptides Intended for the Treatment of Diabetic Retinopathy. Methods: Synthesis of Gold Nanoparticles. Chemical-modification of Polymers and Peptides. In vitro, ex vivo and in Ovo anti-angiogenic efficacy tests, biodistribution analysis, tissue preparation, immunocyto-histochemistry, Transmission Electron Microscopy (TEM), Confocal Microscopy.

Duties: Dispensation and Control of Prescriptions, Providing Pharmaceutical Care and Advice to Patients, Sales of Over The Counter (OTC) products, Control of the Stock.

Title of the Project: Design and Evaluation of Non-viral Vectors based on Hyaluronic Acid and Solid Lipid Nanoparticles for the Treatment of X-Linked Juvenile Retinoschisin by Gene Therapy. Methods: Gene Therapy, Solid Lipid Nanoparticles Synthesis, qRT-PCR, Sequencing and Development of DNA-plasmids, Immunoassays (ELISA, immunofluorescence), in vivo studies in knock-out animal models.

Practical Sessions at the Department of Pharmacy and Pharmaceutical Technology of Prof. Dr. Pedraz, University of the Basque Country Subjects: Biopharmacy and Pharmacokinetics, Galenic Pharmacy and Pharmaceutical Technology I and II, from the Laboratory of Pharmacy and Pharmaceutical Technology.

Title of the Project: In vivo Evaluation after non-Viral Gene therapy Treatment in knock-out animals for X-Linked Juvenile Retinoschisis. Methods: Carrying out experimental procedures with animals. Surgical Procedures, Explantation of tissues.

Duties: Dispensation and Control of Prescriptions, Control of the Medication, Control of the Blood Pressure, Nutritional advice. Training in development of Compounding Medicine (Certified Course, 2009).

Collaboration in Research Projects conducted by Dr. Alicia Rodriguez-Gascón and Dr. Marian Solinís Aspiazu

Design and Evaluation of Non-viral Vectors based on Hyaluronic Acid and Solid Lipid Nanoparticles for the Treatment of X-Linked Juvenile Retinoschisin by Gene Therapy.

Design and Evaluation of a New Vector for Ocular Gene Therapy based on Hyaluronic Acid, Protamine and Solid Lipid Nanoparticles.