Dr. Markus Krupp

Management of signaling systems within the adverse event database of Global Drug Safety, compliant with FDA Good Pharmacovigilance Practices, ICH topics, and EU GvP Module IX Signal Management. Providing qualitative and quantitative periodic safety outputs using disproportionality analysis of company products VS MedDRA terms based on MGPS and PRR. Interfacing medical and technical departments to harmonize mutual understanding and efficient collaboration to provide PSUR and RMP reference data.

- Systems management & administration, including Cluster, Database- & Web-Server - Several biomedical & bioinformatics projects, highlighted projects: -- Analyzing gene expression data (Microarray & Generation Sequencing) in order to develop a functional compendium on serious diseases. -- Analysis of genetic time series profiles of liver transplanted patients to reveal genetic markers predicting the patients benefit of liver transplantation. -- The generation of a functional cancer map

Diploma thesis: “Integration of biological databases and application to environmental genomics”: - Integration of KEGG: 'the Kyoto Encyclopedia of Genes and Genomes' into STRING: 'Search Tool for the Retrieval Interacting Genes/Proteins' - Application of pathway data to environmental genomics

Student research project: “Merck Pathway Database: design and implementation“: - Designing a schema and implement a Merck pathway database (MPD) to facilitate pathway data integration and analysis - Benchmarking the quality of the MPD with respect to TransPath