At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

The Position

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Roche.

In Roche´s Pharma Research and Early Development organisation (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

The Computational Sciences Centre of Excellence is a global organisation enabling Roche’s Research and Early Development units to develop novel therapeutics that will have an impact on patient lives. Within the Computational Sciences Centre of Excellence, the Computational Biology and Medicine department focuses on furthering our understanding of disease pathogenesis, patient populations, and target biology by having access to the largest Pharma R&D datasets in the world. In partnership with our scientists across pRED, we create better medicines by augmenting every part of R&D through our data-driven culture.

The Opportunity:

We are seeking a highly motivated computational scientist to join our Ophthalmology therapeutic area. In this role, you will be a key member of an interdisciplinary team dedicated to advancing our understanding of ocular diseases. Your primary goal will be to analyze and interpret complex, high-dimensional data to identify novel therapeutic targets and biomarkers. As Roche continues to build and advance its capabilities in computational and data-driven R&D, this position offers an integral role in our strategy. You will collaborate closely with leading laboratory scientists and clinicians, contributing directly to a pipeline of innovative medicines for patients with debilitating eye diseases. You will also be part of the wider Computational Biology and Medicine unit of the Computational Sciences Centre of Excellence drawing on the shared experience and expertise of colleagues globally. Your success is measured by the success of your team and the contribution to the pRED/Pharma goals.

Data Analysis & Insight Generation

• Lead the analysis of high-dimensional datasets such as single-cell, spatial, proteomics, metabolomics, and human genetics data to support therapeutic and biomarker development.

• Partner closely with AI/ML colleagues to apply sophisticated statistical methods to enable drug discovery efforts in Ophthalmology.

• Deliver clear and objective data-driven insights to inform portfolio decision-making.

Collaboration & Strategy

• Contribute to the data and analytics strategy for Ophthalmology efforts in collaboration with partners in the therapeutic area.

• Develop effective working relationships with key stakeholders in the disease therapeutic area, laboratory teams, and computational teams.

• Represent the Computational Biology team as a trusted scientific partner.

Team & Culture

• Contribute to a collaborative workplace culture of scientific rigor, continuous improvement, and open feedback.

• Support the scientific growth of team members by sharing knowledge and expertise.

Who you are:

You are a dedicated scientist with a strong background in applying computational methods to biological problems. You are motivated by scientific challenges and have a clear interest in translating data into meaningful biological insights.

• PhD in Bioinformatics, Biostatistics, Computational Biology, or a similar field.

• Demonstrated experience in drug discovery and/or translational research is highly valued.

• Experience in disease biology is required; specific expertise in ophthalmology is a plus.

• Technical expertise in one or more of the following: analysis of high-dimensional genomic data (e.g., scRNA-seq, spatial data, proteomics, metabolomics), population statistical genetics, or integrative multi-omics from preclinical and/or clinical samples.

• Evidenced programming skills in R and/or Python. Working knowledge of a Linux/Unix environment and experience processing data on an HPC cluster.

• Commitment to clean, well-documented code and reproducible research.

• Strong communication skills with the ability to present complex results clearly to both specialist and non-specialist audiences.

• Ability to quickly grasp topics, formulate problem statements, and achieve successful outcomes.

• Ability to work effectively in a collaborative, cross-functional scientific environment. A track record of working alongside experimental scientists.

Unwavering focus, collaborative teamwork, and exceptional delivery are key behaviors that drive our mission of doing now what patients need next. Together, we can be transformative.

If you are passionate about contributing to a committed team and have the dedication to partnership and innovation, Roche is the place for you! Every role at Roche plays a part in making a difference in patients’ lives. Apply now and join us in making an impact!

#ComputationCoE

Who we are

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let’s build a healthier future, together.