At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love.

That’s what makes us Roche.

In Roche’s Pharmaceutical Research and Early Development organization (pRED) , we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

The Position

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Roche .

In Roche´s Pharmaceutical Research and Early Development organisation (pRED) , we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicine. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

The Therapeutic Modalities (TMo) function is part of the Roche Pharma Research and Early Development (pRED) organization. TMo discovers and optimizes innovative drug candidates including small molecules, biologics and nucleic acid-based therapeutics with the goal of delivering novel therapeutic approaches across all pRED Discovery and Translational areas (DTAs).

We are seeking a Scientist with a strong background in recombinant adeno-associated virus (rAAV) gene therapies to join the RNA Technologies group within Nucleic Acid-Based Medicine (NABM) department at pRED. As a member of NABM, you will collaborate with a diverse group of experts, committed to pioneering the next generation of viral and non-viral gene therapies. Together, we cultivate a vibrant and collaborative community, continually exploring and implementing innovative approaches in our research environment.

The Opportunity

Your role will focus on designing and testing AAV gene therapies to advance the development of our drug discovery pipeline.

• You design and experimentally test novel gene therapy payloads using computational tools, AI/ML models, in the relevant cellular systems.

• You collaborate closely with disease experts to integrate genetic and protein elements into functional gene expression systems in mammalian cells.

• You independently design, perform and analyze experiments, to enable fast decision making.

• You engage with pRED disease experts to support new projects and take independent responsibility for experiment design, analysis, and interpretation.

• You supervise and coach staff members to foster a collaborative and productive work environment.

• You demonstrate scientific excellence by publishing research findings and presenting at internal and external scientific meetings.

Who you are

• You hold a PhD in RNA Biology, Molecular Biology, Synthetic Biology or a relevant scientific discipline and have hands-on experience in AAV-based gene therapy and genetic elements design.

• You possess expertise in molecular biology and gene expression regulation (e.g., RNA biology, splicing, RNA engineering, pooled library design).

• Expertise in NGS data generation and analysis is required.

• You bring hands-on experience with computational tools (R, Python) and with AI/ML models, for the design of genetic elements.

• You have a flexible mindset, capable of working on innovative platform approaches and diverse projects/molecules, driven by problem-solving and the generation of high-quality data packages with a sense of urgency.

• You are fluent in English and have excellent communication and presentation skills.

Ready to take the next step? We'd love to hear from you. Apply now to explore this exciting opportunity!

Who we are

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let’s build a healthier future, together.