At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

The Position

A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Roche .

In Roche´s Pharmaceutical Research and Early Development organisation (pRED) , we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicine. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.

pRED's Pharmaceutical Sciences (PS) group enables discovery and development of safe and effective therapeutics at optimal doses in relevant populations with a vision to power translation, continuously improve the accuracy of our predictions and accelerate the development of tomorrow's medicines. PS supports discovery and development across the whole value chain from target assessment to on-market and beyond.

The Opportunity

As a pharmacometrician, you contribute to developing medicines by designing and executing the pharmacometric strategy for programs in different stages of clinical development in one or more indications or disease areas. The pharmacometrics position is located in the Predictive Modeling chapter, where pharmacometrics is a primary focus area, together with other modeling functions in Pharmaceutical Sciences. As a pharmacometrician, you closely collaborate with other functions in pRED and/or development to ensure that the pharmacometric support is addressing the key needs to bring projects forward.

Your key responsibilities:

• Develop and execute scientifically sound, innovative and business-oriented Modeling & Simulation (M&S) strategic plans for projects in various disease areas and different stages of clinical product development, including regulatory submissions.

• Develop and execute appropriate (population) pharmacokinetic and (population) pharmacodynamic models for the project and apply, if available for the project, empirical and/or mechanistically-based drug disease models as well as conduct simulations to inform drug development decisions such as dosage regimen selection and other trial design features.

• Communicate the outcome of M&S analysis to the project teams to support efficient discussion and decision making.

• Contribute to responses to health authority requests and interactions to align on Clinical development and M&S strategy, as well as interact on a scientific level with partners in project team(s) with regards to all aspects of the application of M&S to ensure efficient and appropriate integration of M&S strategy and results into internal and external project documents.

Please note this position is temporary for 2 years.

Who you are

• You hold a PhD in pharmacology, pharmacometrics, or natural sciences, with experience in planning and conducting modeling and simulation (M&S) projects for clinical study data. Previous industry experience is considered valuable.

• You possess a strategic mindset and understand how and when M&S can contribute value in drug development and support decision-making.

• You have significant experience with M&S software, such as NONMEM, Monolix, and R.

• You are curious and have a growth mindset, along with a keen willingness to learn and develop in the area of pharmacometric methodology and strategy.

• You possess excellent written communication and presentation skills with a high fluency in English.

• You are resourceful and flexible in problem-solving, and can work in agile matrix teams with a sense of urgency in a fair, open, and collaborative manner.

Unwavering focus, collaborative teamwork and outstanding delivery are key behaviours that drive our mission of doing now what patients need next. Together, we can be transformative.

If you are passionate about contributing to a committed team and have the dedication to partnership and innovation, Roche is the place for you! Every role at Roche plays a part in making a difference in patients’ lives.

Apply now and join us in making an impact!

Who we are

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let’s build a healthier future, together.