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That is why we come to work every single day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

The Position

We are seeking a highly motivated postdoctoral fellow to join the Immunology Discovery group of the Cardiovascular Metabolism and Immunology Department. The successful candidate will investigate the molecular pathways that drive the regeneration and function of human alveolar cells in homeostasis and under inflammatory disease conditions. Research will focus on targeting Wnt and other signaling pathways using novel pharmacologic modulators to uncover novel synergistic interactions. The overarching goal is to gain a deeper understanding of the fundamental processes of lung regeneration in the context of disease and to devise novel therapeutic strategies.

Key Responsibilities

• High-throughput culture of human alveolar and airway organoids

• Investigating the impact of disease-relevant perturbations to identify conditions that recapitulate the disease molecular state

• Phenotypic and molecular characterization using techniques such as immunofluorescence, flow cytometry, and single-cell RNA-sequencing (scRNA-seq)

• Using pharmacological modulators to understand pathways involved in alveolar cell regeneration and differentiation

• Investigating how modulating the identified signaling pathways can impact the function of alveolar progenitor cells under disease conditions

Qualifications

• PhD in Molecular Biology, Cell Biology, Developmental Biology, Pharmacology, or a related field

• To be eligible for a Roche Postdoctoral Fellowship, you must be within the first four years of completing your PhD in a relevant field at the start of the project

• Strong background in cell signaling, particularly Wnt pathways, and experience with organoid culture systems

• Proficiency in high-throughput screening techniques and data analysis is desired

• Experience with genetic engineering and iPSC technology is desirable

• Proficiency in computational analysis and data interpretation is highly desired

• Excellent problem-solving skills and the ability to work independently and collaboratively in a multidisciplinary team

This position is sponsored by the Roche Postdoctoral Fellowship Programme.

The RPF Programme has the ambition to build and maintain the Scientific Leadership of the future and to provide leading Roche scientists with the opportunity to collaborate with talented postdoctoral researchers, and leading academic research groups, from around the world. One of the key aims is to advance basic science and technologies that will be published in top-rated, peer-reviewed scientific journals, if necessary preceded by priority patent applications.

More information about the RPF Program can be found

The duration of the RPF project is initially set for two years, with the possibility of extension for a third year. You will be based in Basel, Switzerland.

The start date of this fellowship is on availability. Please clearly indicate your preferred starting date in your motivation letter.

All applications always need to include:

• your CV,

• a motivation letter,

• and a publication list.

Do you know what Roche stands for? Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

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Who we are

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let’s build a healthier future, together.

Basel is the headquarters of the Roche Group and one of its most important centres of pharmaceutical research. Over 10,700 employees from over 100 countries come together at our Basel/Kaiseraugst site, which is one of Roche`s largest sites. Read more.

Besides extensive development and training opportunities, we offer flexible working options, 18 weeks of maternity leave and 10 weeks of gender independent partnership leave. Our employees also benefit from multiple services on site such as child-care facilities, medical services, restaurants and cafeterias, as well as various employee events.