Senior Expert Data Science (Make-on-Demand Cheminformatics & AI)
Senior Expert Data Science (Make-on-Demand Cheminformatics & AI)
SIGMA7 GmbH
Pharma, Medizintechnik
- Basel
- Vollzeit
- 72.500 CHF – 115.000 CHF (von XING geschätzt)
Vor Ort
Senior Expert Data Science (Make-on-Demand Cheminformatics & AI)
Über diesen Job
Summary
The mission of Novartis is to reimagine medicine, and our team exemplifies that mission by consistently pushing the boundaries of drug discovery technology and data science. We interface with biologists, geneticists, chemists, and computational experts daily, to execute complex collaborations and bring first-in-class and best-in-class drugs to patients with urgent unmet need. We thrive in the earliest phases of drug discovery, partnering with diverse disease areas to nominate the next generation of drug targets and modalities, as well as elucidate complex biological mechanisms and sites of action.
To extend our impact, we’re seeking a creative, passionate, and tenacious scientist to join the data science team in Discovery Sciences (DSc) at Novartis Biomedical Research (BR). If you want to make a difference in the field of early drug discovery and want to join our dynamic and collaborative team, we encourage you to apply today.
To extend our impact, we’re seeking a creative, passionate, and tenacious scientist to join the data science team in Discovery Sciences (DSc) at Novartis Biomedical Research (BR). If you want to make a difference in the field of early drug discovery and want to join our dynamic and collaborative team, we encourage you to apply today.
About the Role
Major accountabilities:
- Champion Make-on-Demand (MoD) workflows and apply and develop computational strategies and workflows that accelerate hit finding activities
- Develop synthon based searc h strategies to allow teams to leverage ever increasing virtual spaces without having to rely on brute force searches of fully enumerated spaces
-
Contribute to the design of internal Low Molecular Weight (LMW) and DNA Encoded libraries
in order to
fully harness the potential of MoD during hit finding.
- Leverage core expertise in cheminformatics, computational chemistry, and data science, to generate and navigate virtual chemical spaces, build predictive models, collaborate with project teams to accelerate early drug discovery projects .
Minimum Requirements:
- PhD with a cheminformatics, c omputational chemistry, or physics focus ; or alternatively, a degree in a related subject ( e.g. chemistry, chemical biology, computer science, or data science) in combination with the equivalent experience applying computational tools in life science / drug discovery setting .
- Hands on experience with cheminformati c workflows, and familiarity with descriptors and machine learning (ML) in the context of cheminformatics.
- Excellent scientific communication , including the a bility to present complex data science concepts in digestible terms to diverse scientific audiences while leverag ing innovative data visualization.
- Demonstrated a bility to work as part of an interdisciplinary team (i.e., biologists, chemists, data scientists) , with proactive and results-oriented communication skills . Dedication to p romot ing mutual respect, empathy, and positivity in diverse professional settings.
- Expertise working in Linux high performance computing and cloud environments.
- Expertise in Python scientific stacks, familiarity with best practices in computational reproducible research ( version control, testing, documentation).
Nice to have :
- Familiarity with structure-based and ligand-based approaches
- Experience with some of the following: ligand protein docking, generative chemistry, deep learning, ligand protein cofolding
- Familiarity with Large Language Models (LLMs)
- Experience or familiarity with organic synthesis
- Experience designing libraries of small molecules
- Experience using synthons and transformations to generate virtual spaces, or to interrogate virtual spaces
Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.
Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture
Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network
Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards
Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.
