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Your tasks:

The AG Engel looks for a PhD candidate (65%, starting around the 1 st of July 2026). The PhD position is integrated in a DFG-funded consortium (see below). The person will mainly work with hiPSC-cardiomyocytes and -endothelial cells. Goal is the biofabrication of a vascularized functional human heart ventricle model with acellular heart valves. Your task is 1) to optimize materials to enhance vascularization, 2) to establish 3D printing technologies to integrate a main vasculature into a human heart ventricle model, 3) to establish a microfluidic system to test bioinks for their suitability for hiPSC-cardiomyocytes and -endothelial cells. 4) to establish systems to determine function of the ventricle model. The hired candidate will be supported by 2 postdocs, 2 PhD students and 2 technicians who all work on related projects.

Essential experience/qualifications:

• Diploma or Master's degree in Tissue Engineering, Material Science, Biology, Chemistry, Molecular Medicine or equivalent
• English language skills
• highly motivated and reliable
• working well in a team

Additionally beneficial are:

+--------------------------------+ | Experience in: - hiPSC culture | | and differentiation - cell | | culture in general - tissue | | engineering/biofabrication | | - microfluidics - | | vascularization - publishing | | In addition, some German | | language skills would be | | helpful but not necessary (the | | lab is international). | +--------------------------------+

Comments:

+--------------------------------+ | - This position is part | | of the CRC/TRR225. The | | Collaborative Research | | Centre/Transregio CRC/TRR | | 225 "From the Fundamentals | | of Biofabrication towards | | Functional Tissue Models” is | | an interdisciplinary research | | consortium of the Universities | | of Würzburg, Bayreuth, | | and Erlangen-Nürnberg. - | | The TRR225 aims to develop | | innovative biofabrication | | strategies - particularly | | automated 3D printing | | technologies - for | | processing living cells and | | biomaterials into complex | | tissue constructs. These | | advanced in vitro models | | provide new opportunities | | for pharmaceutical, cancer, | | and infection research, | | support the reduction of | | animal testing and offer | | long-term perspectives for | | regenerative medicine. - Since | | its establishment in 2018, | | the consortium has achieved | | substantial scientific | | progress and international | | visibility and will enter its | | third funding period in 2026. | | - The advertised position | | is part of the subproject | | C01, which focuses on the | | biofabrication of vascularized | | heart substitute tissues based | | on bioinks from spider silk | | proteins. This project will | | address the following work | | packages: 1) Establishing and | | optimization of 3D bioprinting | | procedures of silk/collagen-I | | composite gels and elucidating | | matrix remodeling 2) | | Vascularization of cardiac | | constructs 3) Optimization | | of ventricle-like heart | | constructs and integration of | | heart valves | +--------------------------------+

We offer:

• The head of the lab, Prof. Engel, is educated as engineer, received a PhD in molecular medicine, habilitated in cell and developmental Biology and has acquired experience in biofabrication
• The lab publishes regularly in high impact factor journals including Advanced Materials and the work is highly cited
• This is a TV-L, E13 (65% of regular working hours) position
• The position is limited to the end of 2029
• We are an international laboratory with 5 PostDocs, 8 PhDs and 4 Technicians
• Interdisciplinary laboratory: molecular/cell biology and tissue engeneering working with zebrafish, mice, rats and human material
• Integration in a large, successful project with around 30 Pis and regular meetings.

Further information:

Vorname Nachname: Prof. Felix B. Engel Telefon: +49 (0)9131 85-35659

Applications:

Prof.Dr.rer.nat.Dipl.Ing. Felix B. Engel Head of Experimental renal and vascular research in the Nephropathology Department at the Institute of Pathology Kussmaulallee 12 (TRC) 91054 Erlangen Email: felix.engel@uk-erlangen.de phone: 09131 85-35659

Bereitgestellt in Kooperation mit der Bundesagentur für Arbeit.