We are looking for a highly motivated PhD student to join the translational pediatric oncology research group of Dr. Christian Braun at the Department of Pediatrics (Director: Prof. Jan-Henning Klusmann). Our lab investigates how dysregulated gene expression programs contribute to the development and progression of cancer, with the goal of identifying new therapeutic vulnerabilities. We combine advanced CRISPR-based screening approaches with transcriptomic and proteomic profiling, using patient-derived cancer models to explore the molecular mechanisms that drive high-risk tumors.

Your Role:

• Designing and conducting CRISPR-based genetic screens in cancer models
• Performing statistical analyses of epigenetic, transcriptomic and proteomic datasets
• Validating candidate genes and pathways in vitro and in vivo
• Contributing to the development of targeted therapeutic strategies

• Master's degree in life sciences or a related field
• Strong interest in discovering novel therapeutic approaches and understanding epigenetic mechanisms of gene regulation
• Hands-on experience with standard molecular biology techniques (e.g., cloning, PCR, flow cytometry)
• Proficiency in bioinformatics and the analysis of high-throughput datasets (e.g., RNA-seq, proteomics)
• Ability to work both independently and as part of a collaborative research team
• Excellent communication skills and proficiency in spoken and written English
• Due to legal regulations, valid proof of measles immunity / measles vaccination is required

• The position (65% - E 13 ) is initially limited for 2 years with the possibility for extension
• Excellent scientific environment & dedicated mentoring
• Participation in training and qualification programs of the MSNZ and the Goethe University
• Training in novel cutting edge techniques to study epigenetic mechanisms in cancer
• Collaboration opportunities with national & international world-leading laboratories
• Free public transport in all Hessen (Free State Ticket Hessen)
• Uniklinik-Campus, Mensa, Cafés

Contact: Prof. Dr. Jan-Henning Klusmann
Email: KKJM-direktor@unimedizin-ffm.de
Application Deadline: 08.08.2025

We welcome applications from candidates of all genders. Applicants with severe disabilities will be given preferential consideration in cases of equal personal and professional qualifications.