Leibniz Institute of Plant Biochemistry (IPB), Halle

In the Leibniz Institute of Plant Biochemistry, Dr. Tom Schreiber invites applications for a PhD-position in a three-year DFG-funded project:

(Salary group E13 TV-L, part-time 65%, limited for 3 years, start: as soon as possible)

Who we are:

Our Team develops synthetic and programmable tools for precision genome editing, transcriptome modulation, and sensor-based Reporters. Our expertise spans RNA-guided nucleases, TALE architectures, Argonaute proteins, and emerging RNA-guided systems, which we apply to uncover fundamental principles of protein–nucleic acid interactions and translate them into robust biotechnological applications. We also focus on DNA double-strand break repair and the development of transient, transgene-free delivery strategies to enable precise, HDR-based genome engineering in plants. By integrating synthetic biology, genome repair engineering, and advanced nucleic-acid tool development, we aim to advance scalable and sustainable biotechnology in plants and other eukaryotic systems.

Your tasks:

• Design, clone and test synthetic tools, tailored for plant factors involved in EJ-processes
• Establish and apply the Bindcraft pipeline for the de novo design of peptide binders
• Inhibitor screening via transient expression in Nicotiana benthamiana reporter lines
• Inhibitor-application in stable gene editing approaches using Arabidopsis thaliana reporter lines
• Presentation and publication of scientific data

Your profile:

• Diploma or master’s degree in biology, biochemistry, or closely related field
• Open mindset and enthusiasm for scientific work and work within a team
• Independent and solution-oriented work ethic
• Very good English language skills (written and spoken)
• Ability to work in a multi-cultural, multi-ethnic environment with sensitivity and respect for diversity
• Desirable knowledge and skills include:
• Understanding of the principles that define DNA, RNA, protein structures, functions, dynamics and interactions
• Experience in molecular and plant work (Cloning, CRISPR-systems, transient and stable plant transformations)
• Background in Bioinformatics