Job Family: Discovery & Product Development

Job Type: Full Time

Location : Schlieren, Zürich, Switzerland

Employer Reference: R-263584

CSL's R&D organization is accelerating innovation to deliver greater impact for patients. With a project-led structure and a focus on collaboration, we’re building a future-ready team that thrives in dynamic biotech ecosystems. Joining CSL now means being part of an agile team committed to developing therapies that make a meaningful difference worldwide.

We are seeking a Therapeutic Area (TA) Pharmacology Lead (Cardiovascular & Renal) to drive the design, execution, and interpretation of in vivo pharmacology studies that support drug discovery and development. This role is pivotal in characterising the pharmacological profile of novel therapeutic candidates through internal studies and external collaborations.

Main Responsibilities

Scientific Leadership​

• Define and lead the nonclinical pharmacology strategy for discovery and development programs within the relevant therapeutic area (Cardiovascular and/or Renal)

• Design and oversee in vivo efficacy, pharmacodynamic (PD), and mechanism-of-action studies in relevant animal models.​

• Guide the selection and validation of disease models that best represent human pathophysiology.​

Study Design & Execution​

• Develop and implement study protocols for pharmacology, target engagement, and biomarker evaluation.​

• Select external collaborators or CROs and collaborate with internal teams, academic collaborators or CROs to ensure high-quality and timely execution of pharmacology studies.​

• Analyze and interpret complex data sets to inform compound progression and candidate selection.​

Cross-Functional Collaboration​

• Act as Sr. Pharmacology lead on TA teams.​

• Work closely with PK, Toxicology, Translational Science, to integrate pharmacology data into broader development plans.​

• Participate in project teams and TA-teams and provide expert input on pharmacology-related issues.​

• Provide expert input into due diligence for in-licensing or partnership opportunities.​

Documentation & Communication​

• Prepare study reports, presentations, and regulatory documents (e.g., IND, CTA).​

• Present findings to internal stakeholders and external collaborators as needed.​

Team Leadership:​

• Lead and mentor a team of Principal and Sr. scientists, incl. in-vivo lab work.​

• Foster a culture of scientific excellence, innovation, and continuous learning.​

Qualifications and Experience Requirements:

• Ph.D. in Pharmacology, Physiology, Biomedical Sciences, or a related field.​

• 10+ years of experience in nonclinical pharmacology within the pharmaceutical or biotech industry or academic background with proven and deep understanding of pharmaceutical development​

• Strong expertise in in vivo pharmacology, disease models, and translational science for the relevant TA (Cardiovascular and/or Renal Disease Biology).

• Familiarity with regulatory expectations for nonclinical pharmacology data.​

• Proven ability to manage multiple projects and timelines.​

• Strategic thinker with excellent problem-solving, communication, and interpersonal skills.

• Experience across multiple therapeutic areas and modalities is highly desirable

• Extensive knowledge in one of Cardiovascular or Renal Biology is essential; both would be viewed highly favorably.

Are you interested? We are looking forward to receiving your online application.