Dr. Holger Schmitt

Organisationsentwicklung, Personalentwicklung und Supervision für Unternehmen • Change Management • Transformationsbegleitung • Coaching und systemische Arbeit für Einzelpersonen.

• Clinical development project team lead • Global clinical trial team lead • International clinical trial management phase I-IV • Therapeutic areas: oncology, pain management, palliative medicine, respiratory medicine • KOL and advisory board management. CRO oversight. Quality management system (QMS).

• Medical strategy and clinical operations • Clinical trial team lead • Global clinical trial management (phase I-IV, NIS) • Therapeutic areas: gastroenterology, oncology, pain management, palliative medicine • Patient Reported Outcome (PRO), Health-Related Quality of Life (HRQoL) • KOL and advisory board management. CRO oversight

• Medical strategy and clinical operations. • Clinical trial team lead • Global clinical trial management (phase I-IV, NIS) • Therapeutic areas: gastroenterology, oncology • Patient Reported Outcome (PRO), Health-Related Quality of Life (HRQoL) • KOL and advisory board management. CRO oversight

• Molecular biology and automation technologies (robot-aided substance handling, DNA microarrays, protein chips) for research and drug development • Strategic and technical consulting of academic and industrial customers • Identification and assessment of new technologies • Customer acquisition, contract negotiation and key account management. • Macroarrays, microarrays, high-density oligonucleotide arrays (GeneChips), microelectronic arrays (NanoChip). Multiple Application Systems (QBot).

Institut für Anthropologie und Humangenetik, Abteilung Molekulare Genetik. • Team Leader ‘Genome Mapping’. • Research areas: human genome mapping and DNA sequencing, Bacterial Artificial Chromosomes (BACs), FISH, automation technologies, molecular diagnostics, the Human Genome Project (HGP).

Institut für Anthropologie und Humangenetik, Abteilung Molekulare Genetik. • Physical mapping of human chromosome 22 with the Bacterial Artificial Chromosomes (BACs) cloning system. • Establishing fluorescence in situ hybridization (FISH) with CCD camera detection (charge-coupled device) and automated analysis for clinical diagnostics.

Dr. Senckenberg Anatomie, Zentrum der Morphologie • Fluorescent tissue in situ hybridization in mouse model for Alzheimer’s disease.

Institut für Humanbiologie und Humangenetik. • Preparation and analysis of human chromosomes for prenatal diagnosis from amniocenteses and chorionic villi biopsies. • Human genetic diagnostics, prenatal diagnosis.

• establishing the BAC cloning system and genomic libraries for human genome sequencing within the Human Genome Project • advancement of automation technologies • physical mapping • multiplex DNA sequencing • fluorescent in situ hybridization (FISH) • comparative genome hybridization (CGH)

• development of the new cloning system Bacterial Artificial Chromosomes (BACs) • research areas: human genome mapping and sequencing, human chromosome 22.

• Humangenetik • Molekulare Genetik • Anthropologie • Humangenom-Kartierung • Fluoreszenz in situ Hybridisierung (FISH) • Chromosom 22 • Bacterial Artificial Chromosomes (BACs)

• Humanbiologie • Molekulare Genetik • Tumorbiologie • Mikrobiologie • Zellbiologie • Pränataldiagnostik • Telomere • nicht-radioaktive Hybridisierungsmethoden