Dr. Sebastian Jarzina

Assessment of systemic toxicity in vitro using the Adverse Outcome Pathway (AOP) concept: nephrotoxicity due to lysosomal overload and inhibition of mtDNA polymerase-g as case studies Project: - Integrating mechanisms and quantitative in vitro-in vivo extrapolation (QIVIVE) modelling for risk assessment based on in vitro testing (Risk-IT) -

Development of a phenotypic screening assay for assessing drug induced liver injury using embryo zebrafish

Acute toxicity of six drugs using larval zebrafish

Establishment of a new culture method called hanging drop method to assess drug induced liver injury

The use of telemtry in minipigs

Establishment of co-culture system using skin models in combination with keratinocyte reporter cell line, LuSens Establishment of a co-culture system using skin models in combination with dendritic cells Evaluation of a artificial membranes (PAMPA) in combination to LuSens assay for the identification of poor water soluble skin sensitizers

Development of a novel in vitro co-culture approach for assessment of skin sensitization potential

Establishment of a method for skin sensitization potency determination using in vitro 3D skin models

Development of a Bacterial Artificial Chromosome

Establishment of a recombinase mediated cassette exchange (RMCE) - system for a tetracycline (Tet) controlled expression of genes in chinese hamster ovary cells and human embryonic kidney 293 cells