Description:

We are seeking a highly motivated PhD student to join a multidisciplinary research project focused on developing viral-based tools for specific labelling and functional manipulation of transcriptionally defined neuronal subtypes.

The project integrates RNA sequencing analysis with state-of-the-art approaches in neuronal manipulation, including PSAMs and DREADDs , to identify and validate enhancer-driven viral constructs for selective labelling and manipulation of neuronal subtypes.

The research program is structured into three main objectives:

1. Bioinformatics analysis to identify subtype-specific enhancers.
2. Experimental validation of candidate enhancers.
3. Development and testing of enhancer-driven viral constructs for neuronal manipulation.

Further information about the research team and department is available here:
University of Augsburg – Translational Anesthesiology and Intensive Care

Key Responsibilities

• Conduct bioinformatic analyses using enhancer databases and deep learning tools to establish selection criteria for enhancers.
• Establish and optimize primary neuronal cell cultures .
• Perform viral production and carry out quality control assays.
• Contribute to data analysis, interpretation, figure preparation, and manuscript writing .
• Collaborate with internal and external partners and actively participate in lab meetings, training sessions, and conferences.

Required Qualifications

• Master’s degree (or equivalent) in Neuroscience, Biology, Bioinformatics , or a related discipline.
• Proven experience in programming/coding (Python, Matlab, or R) and willingness to learn new approaches.
• Hands-on experience with primary neuronal cell culture .
• Familiarity with viral tools (e.g., AAVs).
• High level of motivation, reliability, and independence , combined with the ability to work effectively in a team.
• Strong written and verbal communication skills in English .

What We Offer

• A 65% TV-L E13 funded PhD position , initially funded for a period of 2 years (with the possibility of extension).
• Access to cutting-edge technologies and a collaborative research environment.
• Integration into an internationally oriented research community .
• Support for presenting your work at national and international conferences .

Application Procedure

To apply, please submit the following documents in a single PDF:

• Cover letter outlining your research interests and relevant experience.
• Curriculum vitae (CV).
• Names and contact details of at least one academic references .

For further enquiries please contact: Dr. Ouamayma Aousji (Oumayma.Aousji@uni-a.de)

Translational Anesthesiology und Intensive Care Universityhospital Augsburg Stenglinstr. 2 86156 Augsburg

Email: Volker.Eulenburg@med.uni-augsburg.de