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The Position

We are offering a unique opportunity to join the Structural Biology team in the Roche Innovation Center in Basel.

The Internship is based within Lead Discovery, a part of Roche Pharma Research and Early Development, in collaboration with Antibody and Protein Technologies of Roche Diagnostics. The Structural Biology team delivers cutting-edge structural insights for all research and development across Roche, including small and large molecule research, genomic medicine and diagnostic solution. We are a diverse group of individuals with a broad range of deep expertise in X-ray crystallography, cryo electron microscopy (cryo-EM), protein purification and biophysical methods. We are looking for a talented master or bachelor student to support the structural biology team in delivering high quality protein structures and insights for our Diagnostics colleagues. The student will have access to world-class X-ray crystallography and cryo-EM facilities. This is a fantastic opportunity for someone who wants to further their practical knowledge in cryo-EM and X-ray crystallography methods while obtaining insights into how these methods are applied in the diagnostics and pharmaceutical industry.

The Opportunity

• Be integrated into the Structural Biology team within Lead Discovery.

• Work closely in a highly collaborative spirit with Diagnostics colleagues in Germany and USA.

• Perform and learn wet-lab experiments on proteins, such as high-throughput crystallisation screening, cryo-EM grid preparation and SPS-PAGE analysis, with the ultimate aim of generating 3D protein structures.

• Use and learn IT tools to solve and build protein structures by X-ray crystallography and/or cryo-EM.

• Plan experiments independently and present your results to stakeholders and within group seminars.

• Learn how structural biology is a key tool in drug discovery and diagnostics research.

Who You Are

• You should be enrolled in a Master’s program or be a recent graduate (within 12 months of the start date) in biochemistry, biology, biophysics or a related scientific field with a background in structural biology.

• You are dedicated and willing to learn on-the-go, take ownership of projects and have excellent organisational skills.

• You have excellent communication skills and are able to communicate with multiple stakeholders and multi-task projects.

• You have professional fluency in English, both written and verbal.

• You have some prior hands-on experience in either X-ray crystallography or cryo-EM (other biophysical methods, protein expression/purification and/or Linux fluency is a plus).

Application Process

• Please upload your CV, a motivation letter with your application, and a certificate of enrolment (if you are currently studying).

• Non-EU/Non-EFTA citizens must attach a confirmation from the university to the application documents, stating that a mandatory internship is part of the education.

Additional Information

• This position is based in Basel, Switzerland.

• The earliest start date for this internship is September 2026, with a minimum duration of 9 months.

If you are passionate about collaboration and innovation, Roche is the place for you! Every role at Roche plays a part in making a difference in patients’ lives. Apply now and join us in making an impact!

Who we are

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let’s build a healthier future, together.

Roche is an Equal Opportunity Employer.