Dr. Sarah Ayash – Junior Group Leader, Einstein Independent Researcher

Project Overview:

We are seeking a highly motivated PhD student to join a multidisciplinary research project aiming to decode the neural mechanisms underlying resilience to social stress , with a particular focus on the mesolimbic dopamine system . The project combines an ethologically valid chronic social defeat (CSD) mouse model with cutting-edge tools in circuit neuroscience , including fiber photometry and optogenetics to investigate threat-safety discrimination and extinction responsiveness as core features of stress resilience.

The research is structured into three main aims, spanning from causal manipulation of dopamine circuits, through sex-specific analyses, to pharmacological interventions.

Key Responsibilities:

• Perform fiber photometry recordings using genetically encoded dopamine sensors in freely moving mice to monitor dopamine during different behaviors.

• Conduct optogenetic manipulations.

• Establish and refine behavioral paradigms for social stress and interaction in both male and female mice.

• Perform pharmacological interventions to evaluate reversal of susceptibility phenotypes across sexes.

• Contribute to data analysis, interpretation, figure generation, and manuscript preparation.

• Collaborate with internal and external partners and participate in lab meetings, training, and conferences.

Required Qualifications:

• Master’s degree (or equivalent) in Neuroscience, Biology, Psychology, Pharmacology, or a related discipline.

• Experience with in vivo behavioral experiments in rodents , ideally involving stress, social behavior, or learning.

• Familiarity with optogenetics and/or fiber photometry .

• Experience with stereotaxic surgery , animal handling, and post-operative care.

• Data analysis skills (Python, MATLAB, or similar), and willingness to learn new methods.

• High level of motivation, reliability, and capacity for both independent and team-based work.

• Good written and verbal communication skills in English.

What We Offer:

• A fully funded PhD position.

• Access to cutting-edge in vivo technologies and behavior suites.

• Integration into an internationally renowned research environment at Charité.

• Opportunities for training in circuit neuroscience, data analysis, and professional development.

• Support for presenting your work at national and international conferences.

How to Apply:

Interested candidates must apply exclusively via the Charité application portal using the following link:
https://karriere.charite.de/en/job-vacancies/detail/5715

Please include a cover letter, CV, academic transcripts, and the names/contact of two references. Applications submitted via email will not be considered.

Please note, feedback on the applications will be provided by the end of October not before.