The Max Delbrück Center for Molecular Medicine in the Helmholtz Association aims to transform tomorrow’s medicine through our discoveries of today. At locations in Berlin-Buch, Berlin-Mitte, Heidelberg and Mannheim, our scientists collaborate across disciplines to unravel the complexities of disease at the systems level – from molecules and cells to organs and entire organisms. Through strong academic, clinical, and industry partnerships, as well as global networks, we translate biological insights into innovations for early detection, individualized therapies, and disease prevention. Founded in 1992, the Max Delbrück Center is home to a vibrant community of 1,800 people from more than 70 countries.

We are seeking a highly motivated and talented Postdoctoral Researcher (m/f/d) to join the lab of Michela Di Virgilio at the Max Delbrück Center for Molecular Medicine (MDC), Berlin. This fully funded position offers an exciting opportunity to investigate the molecular mechanisms of genome integrity and diversification in an internationally recognized research environment.

About the Lab – Our group studies the fundamental processes that safeguard genome stability while enabling controlled genome diversification, particularly in contexts relevant to immune function and genomic plasticity. We are currently expanding our research directions to explore how DNA repair capacities vary across distinct cellular contexts and how this diversity contributes to broader phenotypic outcomes. We are also interested in how such context-dependent repair features could inform future approaches to genome manipulation. We aim to dissect and ultimately rewire the logic of DNA repair to uncover how genome integrity is balanced with cellular adaptability across physiological and pathological contexts. Our work has implications for understanding immune resilience, genome instability syndromes, and future genome engineering strategies. We combine mechanistic approaches with advanced cell systems and are part of a vibrant research community at MDC, with strong ties to Berlin’s broader biomedical landscape. MDC offers structured postdoctoral training programs, access to cutting-edge technology platforms, and opportunities for interdisciplinary collaboration across the Berlin biomedical research hub.

Job Description

• investigate mechanisms that maintain and diversify genome stability
• analyze context-dependent DNA repair processes across different cell types
• develop novel approaches for targeted genome manipulation
• work with advanced cell model systems (including gene editing and iPSC-derived models)
• plan and conduct independent research projects
• collaborate within the lab, across MDC, and with external partners
• present and publish research findings, apply for funding

Requirements

We are looking for a researcher (m/f/d) with:

• a PhD in molecular biology, genome stability, chromatin biology, immunology, or a related field
• background in DNA Repair and Genome Integrity is welcome; a genuine interest in these areas is essential
• previous experience in somatic gene editing or iPSC-derived model systems is especially encouraged
• scientific curiosity, independence, and a collaborative mindset
• excellent communication skills in English
• motivation to develop intellectually owned research directions and pursue visibility through funding applications

We offer

• international working environment with communication in English and German
• interesting career opportunities and a range of opportunities for further qualification and training
• Compatibility of family and career certified by the workandfamily audit ("berufundfamilie audit")
• Support for "New Berliners" through the MDC Welcome & Family Office

You also benefit from:

• a remuneration in accordance with the collective agreement for the federal public service (TVöD Bund), including additional company pension schemes
• a centrally funded postdoctoral position, initially for two years, with potential for extension
• career development support, including encouragement and mentoring for competitive fellowship applications
• a collaborative and international atmosphere with strong scientific exchange
• childcare support
• an idyllic green campus, which is easily accessible by bicycle, public transport or car
• free use of Nextbike from the Buch S-Bahn station to the campus
• subsidy for the job ticket as well as discounts in the campus canteen
• on-campus health and fitness center
• additional health benefits such as flu vaccination, eye test, ergonomics advice at the workplace

Salary

Remuneration will be according to the TVöD Bund, depending on the personal requirements, up to the fee group 13.

Employment volume

Desired starting date

Initial contract is for 2 years with potential extension based on performance and funding

Application period

Commitment to Equity, Diversity and Inclusion

Excellence in science and innovation depends on a diverse, inclusive, and respectful environment. At the Max Delbrück Center, we are committed to creating such a space — one where individuals from all backgrounds can grow scientifically, professionally, and personally. As a values-driven research institute, we recognize that diversity of thought, experience, and identity is essential to our mission: advancing biomedical research to transform tomorrow’s medicine. We foster a culture of curiosity, creativity, collaboration, and shared responsibility for equity and openness. We welcome applications from individuals of all genders, cultures, backgrounds, and life experiences, especially those who bring new perspectives and a collaborative spirit to our international team. Applicants are considered based on qualifications and experience, free from discrimination. We particularly welcome applications from individuals with disabilities and will ensure appropriate support is provided.

Please get in touch with any questions

Casey Bass-Clements
AG Di Virgilio
caseydale.bassclements@mdc-berlin.de

Please submit the following documents as a single PDF file:

• Your CV
• Contact information for two academic references
• Crucial: A cover letter outlining your research background, scientific interests, career trajectory, and an explanation of how joining the lab as a postdoctoral scientist fits into your long-term career plan
• Optional: A one-page, non-AI-generated project proposal that you would like to develop

For information on fair mobility, click here: https://www.fair-labour-mobility.eu/ .