Postdoctoral position in Bioinformatics/Computational Biology (m/f/d) (full-time position 100 \%

Arbeitsplatz

2025-10-21+02:00 -

2025-10-22+02:00 -

The University Hospital Bonn (UKB) is a maximum care hospital with more than 1,300 beds. Our more than 9,000 employees take on tasks in research, teaching and patient care as well as in public health at the highest level. In the science ranking (LOMV) and in the economic result, the UKB is number 1 of the university hospitals in NRW and in 2021 had the third highest case mix index of the university hospitals in Germany. The group of Prof. Dr. med. Kaan Boztug at the Clinic of Pediatric Immunology and Rheumatology (Centre of Pediatric, University Hospital Bonn) offers a Postdoctoral position in Bioinformatics/Computational Biology (m/f/d) (full-time position 100 \% ~ 38,5 h/week) The position is offered as a fixed-term appointment until 30 September 2032, corresponding to the duration of the professorship. Join a Leading Research Program in Childhood Immune Dysregulation The newly established Clinic for Pediatric Immunology and Rheumatology at the University Hospital of Bonn, led by the Director, Prof. Kaan Boztug, is seeking a highly motivated and talented Postdoctoral Fellow in Bioinformatics/Computational Biology to join an interdisciplinary team investigating the genetic and molecular mechanisms of inborn errors of immunity (IEI), autoimmunity, and autoinflammation. Our research program integrates fundamental discoveries in immune dysregulation with translational medicine, aiming to uncover novel disease mechanism and develop targeted therapeutic approaches. Recent high-impact publications have uncovered monogenic causes of immune-mediated diseases, including Wang L et al., Nature Genetics 2021; Salzer E et al., Sci Immunol 2020; Block J et al., NEJM 2023; or Ransmayr B et al. Sci Immunol 2024. Our group also employs cutting-edge computational and systems biology approaches to support the diagnosis of IEIs and better understand cancer syndromes. These integrative analyses are central to translating genomic data into clinical insights (e.g., Haimel et al., J. Allergy Clin. Immunol. 2021; Guthrie J et al., Sci Adv 2023, Haladik et al., Cell Reports Medicine 2025). The position will focus on the computational analysis of multi-omics datasets (genomics, transctiptomics, proteomics, metabolomics and single-cell and spatial omics) to uncover disease pathways and therapeutic targets in pediatric patients. The candidate will work in close collaboration with wet-lab scientists and clinicians, contributing to the functional interpretation of genetic variants and the modelling of immunopathological pathways. The position will be closely integrated with other computational biologists at the ImmunoSensation2 Cluster of Excellence and other research groups. The project will integrates: • Analyis of multi-omics data (WES/WGS, scRNA-seq, -omics) • Variant interpretation and priorization in monogenic immune disorders • Pathway modeling and network-based approaches • Systems immunology integration of molecular and clinical data • Collaborative projects involving patient-derived samples and model organisms What we offer: • A dynamic, international and interdisciplinary working environment with a strong focus on immunology • Close collaboration with leading scientists in the field of pediatric immunology and rare immune disorders • Opportunities for professional development and career advancement within the research community • Integration into the Excellence Cluster of ImmunoSensation2 with an interdisciplinary network of excellent scientists • Excellent core facilities to support your research across the campus • Salary according to the German salary scale TV-L EG13 (100\% including additional benefits) • Flexible for families: flexible working time models, the option of a place in the company day-care center and offers for those returning from parental leave • Provision for later: company pension scheme • Clever to work: Possibility of an interest-free loan to buy an e-bike • Tailor-made education: Subsidized further education and training • Systematic start: Structured induction • Healthy at work: Numerous health promotion offers, free membership in UKBfit • Employer benefits: preferential offers for employees (corporate benefits) Requirements: • A PhD in Bioinformatics, Computational Biology, Systems Biology, or a related discipline • Proven experience in multi-omics data analysis, variant interpretation, and/or statistical genomics • Extensive knowledge and practical experience of NGS • Experience in the usage of R (including package development) and command line-based analysis tools (e.g. Python) • Knowledge with public sequence databases, error correction algorithms • Scientific experience in immunology, molecular and cell biology would be a plus • Strong English skills with excellent writing and presentation abilities • Enthusiastic and collaborative work attitude We are committed to diversity and equal opportunities. Our goal is to increase the proportion of women in areas where women are underrepresented and to particularly promote their careers. We therefore urge relevantly qualified women to apply. Applications are treated in accordance with the State Equal Opportunities Act. Applications from suitable people with proven severe disabilities and those of equal status are particularly welcome. Applicants should send their application in a single pdf file (max. 5 MB) including a motivation letter, CV, scanned academic degrees, list of publications and the contact details of two references until 18th of November to Prof. Dr. med. Kaan Boztug recruiting.boztug@ukbonn.de kaan.boztug@ukbonn.de Center for Pediatric and Adolescent Medicine Department of Pediatric Immunology and Rheumatology University Hospital Bonn Venusberg-Campus-1 53127 Bonn

Vollzeit, befristet bis 2032-09-30+02:00 ,

53127 Bonn

10001-1002021552-S

Agentur für Arbeit Bonn recruiting.boztug@ukbonn.de

Universitätsklinikum Bonn AöR

http://www.ukbonn.de
Venusberg-Campus
1
Bonn
53127

http://www.ukbonn.de

2025-10-22