500 Menschen aus 50 Ländern arbeiten am Max-Planck-Institut für Molekulare Zellbiologie und Genetik (MPI-CBG) und lassen sich von ihrem Forscherdrang antreiben, um die Frage zu klären: Wie organisieren sich Zellen zu Geweben? Das Institut bringt Menschen aus den verschiedensten Disziplinen zusammen, was neue Einsichten und Erkenntnisse eröffnet.

The research group of Nagaraja Chappidi investigates how macromolecular assemblies and compartment-like structures contribute to accurate DNA replication and DNA repair. The research combines purified replication and repair factors with quantitative biochemical and biophysical approaches—such as TIRF microscopy and optical tweezers—and integrates these findings with cell-based and, where appropriate, disease-relevant models. Key questions include how replication and repair factors self-organize into mesoscale structures, which emergent biophysical properties arise from this organization, and how such compartmentalization improves accuracy, efficiency, and regulation of genome maintenance. The overarching goal is to define the principles governing coordinated factor assembly, selective compartment formation, spatial confinement of enzymatic activities, and the timely exchange of substrates between molecular players.

As a postdoc in the Chappidi group, you will drive independent and collaborative research to dissect the mechanistic principles of compartmentalization in DNA replication and DNA repair. Depending on your background and interests, you may contribute to:

• reconstituting multi-protein assemblies
• performing quantitative single-molecule or imaging experiments
• developing novel biophysical or biochemical assays
• validating emergent principles in mammalian cells or disease models
• integrating concepts across biophysics, biochemistry, and genome maintenance

You will also present your findings at internal meetings and international conferences, contribute to publications, and support a positive and collegial team culture.

Essential qualifications:

• Doctoral degree (PhD) in Molecular Biology, Biochemistry, Cell Biology, Biophysics, or a related life-science field.
• Strong motivation, reliability, and ability to work both independently and with a team.
• Experience contributing to scientific publications or presentations.
  Excellent written and verbal communication skills in English.

Desirable skills and experience:

• Knowledge and hands-on expertise in single-molecule biophysical methods (TIRF microscopy, optical tweezers)
• Protein biochemistry, including purification and quantitative assay development
• Cell-based techniques (mammalian cell culture, imaging)
• Effective collaboration in interdisciplinary teams
• Strong analytical reasoning and persistence in experimental work

• A full-time position in a vibrant, international research environment
• An initial contract of 2 years, with the possibility of extension upon mutual agreement
• Salary and social benefits in accordance with TVöD Bund (up to EG13), based on experience
• Attractive public-sector benefits (VBL pension plan, 30 days annual leave, full social coverage)
• Discounted public-transport job ticket (VVO) and excellent transport connections
• Support for work–life balance, including assistance with family and childcare matters
• A broad network for career development and training through the Max Planck Society

Please submit your complete application via our online system at https://careers.mpi-cbg.de/jobs/61324307/Postdoctoral-Researcher-m-f-d-in-Macromolecular-Compartmentalization-and-Genome-Stability/ stating 2025-Postdoc-GenomeCompartmentalization-2560 by 7 January 2026.
Kindly include the following:

• Curriculum Vitae (CV) including publication list
• A one-page motivation letter
• A two-page statement of research interests and scientific achievements
• Contact details of at least two referees as a single pdf file

Scientific inquiries can be sent to Nagaraja Chappidi ( chappidi@mpi-cbg.de ). Questions regarding contract, compensation or benefits may be addressed to Brian von Rueden ( hr@mpi-cbg.de ).

Max Planck Institute of Molecular Cell Biology and Genetics
Pfotenhauerstr. 108, 01307 Dresden, Germany
http://www.mpi-cbg.de

• The Max Planck Society strives for gender equality and diversity. We welcome applications from all backgrounds, regardless of gender, nationality, ethnicity, sexual orientation, religion, age, and other components of identity.
• The Max Planck Society specifically aims to increase the proportion of women in the areas in which they are underrepresented. We therefore explicitly invite women to apply.
• The Max Planck Society is further committed to increasing the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals.
• The Max Planck Society supports the compatibility of family and career and is certified according to the "berufundfamilie" ("job and family”) audit.