Infertility affects millions worldwide, yet in many cases the genetic basis remains unknown. Instead of focusing solely on gene-by-gene sequencing, this project aims to uncover the shared molecular mechanisms that drive infertility and open the way for new diagnostics and therapies.

Our recent findings show that infertile individuals share phenotypes associated with genotoxic stress and altered androgen receptor (AR) expression. In this PhD project, you will investigate how the cGAS–STING signaling pathway translates genome instability into pathological changes in gonadal tissues. You will study its role in autophagy regulation, innate immune responses, telomere maintenance, and its interaction with AR signaling in the context of reproductive health.

We are looking for a highly motivated PhD candidate with a strong interest in reproductive biology, molecular genetics, or cell signaling. You will receive advanced training in molecular and cellular biology, reproductive genetics, and mechanistic pathway analysis, and contribute to a project with direct relevance for future diagnostic tools and therapeutic approaches in human reproductive medicine .

You will cover the entire spectrum of wet lab experimental work with the "state of the art” technics

DNA, RNA, Protein work: isolation and analysis with PCR, qPCR, Western blot Immunofluorescence, microscopy, histology Cell culture Develope new methods like gonadal organoids or work with primary patient’s cells Specific data entry, documentation, and archiving work

• Successfully completed a Master’s degree in Cell Biology, Developmental Biology, Genetics or Molecular Biology
• Experience with cell culture and wet lab techniques, including DNA/RNA/protein analyses
• Good command of the English language
• Strong teamwork skills, reliability, and flexibility
• High level of commitment and independent work
• IT skills

• Goal-oriented, individual training and development opportunities
• Working with the latest techniques / technical equipment
• Flexible working hours within the framework of flexitime
• Possibility of doctorate
• Possibility to publish scientifically is offered and supported
• Regular team meetings
• Collectively agreed remuneration (TV-L E13), attractive company pension scheme (VBL)
• 30 days vacation
• Sustainable travel: job ticket
• Family-friendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of care
• Wide range of health, prevention and sports offers

Interested?

Applications will be accepted until 30.10.2025 via e-mail or online.