Die Job@ctive GmbH steht für Kompetenz und Leidenschaft in den unterschiedlichsten Bereichen des Personalmanagements, ganz gleich ob Personalberatung, -beschaffung oder -vermittlung. Wir stellen unseren renommierten Kunden bei Personalengpässen und saisonbedingten Arbeitsspitzen unsere Mitarbeiter zur Verfügung.

This means:

• Develop QSP platform models for multiple oncology mechanisms including:
  • Immune checkpoint inhibitors (IO/ICI) across colorectal, lung, and ovarian cancers
  • Antibody-drug conjugates across lung, ovarian, and colorectal cancers
  • T-cell engagers and bispecifics/trispecifics in multiple myeloma
  • CAR-T therapies in hematologic malignancies
• Create and optimize Virtual Populations to capture patient heterogeneity and support clinical trial design
• Implement new methods to enhance QSP-driven MIDD, including AI/machine learning augmentation for literature screening, model drafting, and virtual population optimization
• Deliver practical results that inform dose and regimen selection, optimal combinations, therapy duration, and study design for active development programs 
• Work as part of a coordinated team under the oversight of a senior pharmacometrician within the PMx Oncology Group 

Your Profile:

• PhD or Master's degree with extensive experience in Quantitative Systems Pharmacology or Systems Biology model development

• Proven scientific track record and practical experience in several of the following areas 
  • Statistical modeling
    • Modeling with differential equations 
    • Scripting languages (R, Matlab, Python)
    • Drug development

• Critical thinking and self-reflective
• Persistent and resilient
• Ability to connect unrelated concept and to generate original or unique ideas
• very deep knowledge in the operational construction of the models
• Experience with QSP models
• Fluency in English required, German would be a plus
• very good communication skills