Kennziffer: 11042

Fixed-term of 3 years | Part-time with 65% | Salary according to TV-L E13

We are UKM. We have a clear social mission and, with our focus on healthcare, research, and teaching, we bear a unique responsibility.

To meet our high standards every day, we are looking forward to your scientific expertise – ideally with you on board!

THE GROUP:

The Emmy Noether-funded research group of Dr. Dr. med. Alexander Busch investigates the regulation of the hypothalamic-pituitary-gonadal (HPG) axis—a key system in human reproductive development and fertility. The group combines clinical cohorts, population-scale genetics, and molecular biology to understand how early life periods, such as minipuberty and puberty, shape reproductive capacity.

The position is embedded in the IMF-funded project "ANDROGEN”, which aims to functionally validate newly identified genetic variants that regulate quantitative spermatogenesis. This integrative project combines GWAS, bulk and single-cell transcriptomics, protein validation, and regulatory reporter assays.

YOUR MISSION:

• Investigate how genetic variants affect male reproductive function
• Perform single-nucleus and bulk RNA sequencing of testicular tissue
• Validate gene expression at the protein level via IHC and Western blotting
• Analyze large-scale transcriptomic data (R, Python)
• Test allele-specific regulatory activity using luciferase reporter assays
• Integrate omics data to identify functional variants affecting spermatogenesis

REQUIREMENTS:

• A Master’s degree in Biology, Molecular Medicine, Biochemistry, Biotechnology, or a related discipline
• Solid wet-lab experience in molecular biology, ideally with tissue or protein work
• Motivation to develop bioinformatics and data analysis skills (training provided)
• Proficiency in English (spoken and written); German is a plus but not required
• Team spirit, communication skills, and scientific curiosity
• Prior experience with transcriptomics and/or reproductive biology

WE OFFER:

• A full 3-year PhD position within a dynamic Emmy Noether group
• A central role in a cutting-edge multi-omics project with direct translational relevance
• Individual mentoring, conference participation, and career development support
• A collaborative, international, and family-friendly work environment

For inquiries, please contact: Dr. Dr. med. Alexander S. Busch, alexandersiegfried.busch@ukmuenster.de

Apply now via our career portal until 27.08.2025 including:

• A motivation letter describing your interest in reproductive biology and genomics
• A brief summary of your laboratory and/or analytical experience
• Your CV
• Names and contact details of 1–2 referees willing to provide a letter of reference

BESTE BEDINGUNGEN: