Kennziffer: 11189

Fixed-term of 3 years | Part-time with 65% (25 hours/week) | Salary according to salary group 13 TV-L | The Department of Cardiology I – Coronary and Peripheral Vascular Disease

We are at UKM. We have a clear social mission and, with our focus on healthcare, research, and teaching, we bear a unique responsibility.

To meet our high standards every day, we are looking forward to your scientific expertise in the Laboratory of Molecular Cardiology based at the University Hospital, Münster, University of Münster led by Prof. Holger Reinecke- ideally with you on board!

PROJECT TITLE:

• Reversing endotoxin tolerance using a trained immunity approach

THE INSTITUTE AND PROJECT:

The inflammation and immunimetablism group at the Molecular Cardiology lab led by Dr. Yahya Sohrabi. His work focuses on studying underlying molecular and cellular mechanisms that regulates metabolism and epigenetic changes in the development of innate immune memory (trained immunity). The goal is to develop trained immunity approach against cardiometabolic diseases and its underlying such as sepsis.

In collaboration with Prof. Mihai Netea and Dr Katarzyna Placek from Life & Medical Sciences-Institute, University of Bonn, we investigate the mechanisms of the reversal of immune tolerance with ultimate goal to improve patient treatment. The key feature of the project is to unveil unknown mechanistic details which are then translated towards innovative preclinical intervention strategies to reverse immune tolerance.

Our group is highly interdisciplinary, international, and uses state-of-the-art techniques spanning a broad range from immunology, cell and molecular biology, omics and bioinformatics. The project is funded by the Deutsche Forschungsgemeinschaft (DFG).

RESPONSIBILITIES:

• Design and conduct experiments utilizing state-of-the-art approaches such as:
• In vitro and ex vivo cell culture, ability to work with different type of primary and stable cells, ability to create knockout or knock in CRISPR/cas9 is plus
• basic and multiomics data analysis,
• Flow cytometric analysis of immune cell populations
• Immunohistological staining and imaging
• Biochemical assays for cytokines and other inflammatory mediators
• Protein analysis
• Collaborate closely with colleagues across disciplines to integrate findings into a comprehensive model of atherosclerosis pathophysiology
• Analyze data, interpret results, and present conclusions through high-quality publications, presentations, and reports
• Contribute to manuscript preparation
• Participate actively in departmental seminars, workshops, and conferences

REQUIREMENTS:

• MSc degree in Biological/ medical Sciences
• Strong background in immunology/molecular biology
• Expertise in one or more of the following areas:
• Flow cytometry-based phenotyping and sorting
• Immunofluorescence microscopy and histopathological evaluation
• Statistical programming languages like R or Python
• Good communication skills in English; proficiency in German desirable but not required
• Willingness to work independently while contributing effectively to collaborative projects
• Willingness to participate in ongoing training programs to enhance expertise and stay up to date with latest methodologies

WE OFFER:

• Comprehensive benefits package including health insurance, pension plan, and family support services
• Access to infrastructure, equipment, and resources
• Opportunities for professional growth, networking, and international collaboration
• Supportive environment fostering your own ideas, innovation, and interdisciplinary exchange

Apply now until October 15 2025 and include:

• Cover letter highlighting relevant experience, interests, and career goals (max. 2 pages)
• Curriculum Vitae with publication list and academic record
• Contact details for two referees familiar with your scientific achievements

BESTE BEDINGUNGEN: