Dr. Daniel Tray

• First-hand experience of QbD drug substance regulatory submissions, authoring design space definition sections • Technical leadership of process stages for high profile projects, engaging with global inter-disciplinary teams: - Support of tech transfer and validation activities in manufacturing plants located in Ireland, USA, Singapore and India - Developing technical packages for a CRO based in China • Leading the UK cross-functional DoE expert group of chemists and statisticians

• Development of robust processes and provision of technical understanding to support the late phase project portfolio - Transfer to pilot plants across the GSK network to manufacture Phase III clinical supplies, incorporating a robustness DoE on ~75 kg scale - Key contributor to technical risk assessments (FMEAs) • DoE subject matter expert, implementing best practice through project consultancy and departmental training

Team member of a global technology department utilising laboratory automation to accelerate the development of GSK's pipeline of small molecule assets - Rapid execution of statistically designed work packages to provide process understanding - Expanding the department's automation capabilities (both hardware and software) - DoE power user and contributor to DoE training, at both departmental and project team levels

Team member of the Medicinal Chemistry department, developing synthetic routes and delivering libraries of compounds for high throughput screening

Chemistry team member working across several departments focussed on process development, medicinal chemistry and custom synthesis: - Development and successful transfer of processes to pilot plant scale - Medicinal chemistry route development and delivery of compounds to support contract research programs - Custom syntheses up to 20L scale, delivering compounds to tight timelines which met customer requirements

Thesis title: Application of Remote Asymmetric Induction using Allylstannanes

Cambridge Tripos specialising in Organic Chemistry