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The Position

In Roche’s Pharmaceutical Research and Early Development organisation (pRED) , we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed. This position is located in ADME, a chapter within the PS function, where the fate of new chemical entities and biologics is a primary focus. The ADME Chapter works throughout all stages of compound development, from lead optimization to candidate selection, all clinical development phases to filing of new drug applications. We closely collaborate with our therapeutic areas and functions to convert hypotheses into innovative therapeutics.

The Opportunity

Plasma protein binding (PPB) is a critical determinant of the pharmacokinetic profile and safety of many drugs/drug candidates. During the project, you will generate experimental data in order to assess mechanistic protein binding interactions in vitro . The main focus will be on how adapted methods can be used to better predict the free/unbound drug available for enzyme or transporter-mediated clearance.

In this position, the following duties fall within your scope:

• You will work in a multi-disciplinary team with a range of in vitro ADME assays (involving equilibrium dialysis & cell culture) and learn how to develop and optimise in vitro models to support the drug development process.

• You will gain insights on drug clearance and drug-drug interactions, which make use of plasma protein binding data.

• You will gain hands-on experience in quantitative LC-mass spectrometry.

• You will analyse data and document experimental results and protocols with the highest

• scientific standards.

Who You Are

• You are a Master’s or PhD student with a background in e.g. biochemistry, pharmacology and/or (molecular) biology with an interest in starting your career in the pharmaceutical industry as an intern.

• You have an (basic) understanding of pharmacokinetics.

• You have experience with in vitro ADME assays, in vitro pharmacology or biochemistry.

• You are familiar with common digital tools for experimental planning, execution, evaluation, data archiving and reporting.

• You have strong communication skills and the ability to work in a team.

• You are able to work independently with minimal supervision and have the ability to solve problems in an innovative way.

• Proficiency in English is required.

Additional Information

• The duration of the internship is 6-12 months.

• PhD students must be enrolled for the entire duration of the internship.

• Please note, due to regulations, non-EU/EFTA citizens must provide a certificate from the university stating that an internship is mandatory as part of the application documents, and must be continuously enrolled in their university or PhD program for the whole duration of this internship.

Ready to take the next step? We'd love to hear from you. Apply now to explore this exciting opportunity!

Who we are

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let’s build a healthier future, together.

Roche is an Equal Opportunity Employer.