Lab Associate for Cellular, functional and soluble Biomarkers

Background:

Pharmaceutical Research and Early Development (pRED) at Roche translates cutting-edge science into transformative medicines to address unmet medical needs. We foster a culture of curiosity, responsibility, and humility to drive life-changing innovation.

The Pharmaceutical Sciences (PS) group supports the discovery and development of safe, effective therapies across the entire value chain. This role is part of the Bioanalytics and Biomarkers (BioAM) Chapter within PS, which develops and applies bioanalytical and biomarker methods in Roche clinical studies. BioAM collaborates closely with therapeutic areas and functions to translate scientific hypotheses into innovative medicines.

Tasks & Responsibilities :

• Designing, developing, and transferring biomarker assays that support Roche clinical trials.
• Leading lead in-house assay development, support method transfers to external CRO partners, and ensure the generation of robust, high-quality biomarker data from method development through to clinical sample analysis
• Self-driven planning, development, troubleshooting and critical analysis of results of analytical methods for complex cellular, functional, and soluble protein biomarkers supporting preclinical and clinical drug development, in full compliance with regulatory and GxP requirements
• Design and execute experimental protocols, generate, analyze, troubleshoot, interpret data, and deliver high-quality reports aligned with project timelines
• Support method transfer and implementation with external partners, ensuring proper documentation and efficient troubleshooting
• Seek, evaluate and introduce novel technologies to enhance biomarker strategies and expand their application across therapeutic areas
• Collaborate with internal/external stakeholders to ensure data integrity, technical and scientific rigor, and timely resolution of technical challenges
• Presentations of activities and results on internal/external meetings
• Contribute to a culture of innovation, continuous improvement, and compliance with Safety, Security, Health, and Environmental (SHE) standards

Must Haves:

• Bachelor’s or Master’s degree (No PhD) in a relevant scientific discipline, with proven industry or CRO experience
• Minimum of 2 years of experience in biomarker assay development within a regulated environment.
• Proficiency across diverse biomarker assay technologies, including:
• Cellular and functional assays: Flow cytometry, pFlow, ELISpot/FluoroSpot, HTRF
  -Ligand-binding assays: ELISA, ELLA, Simoa, Elecsys, MSD
  -Hands-on experience in technology implementation, optimization, and troubleshooting of bioanalytical/biomarker methods
• Strong understanding of GxP principles
• Experience supporting pharmacodynamic biomarker assay development for preclinical or clinical applications
• Scientific credibility demonstrated through relevant publications and/or presentations at external conferences (1-2 is enough)
• You are a proactive team player who values collaboration, continuous learning, and scientific excellence.
• You exhibit a growth mindset and seek feedback to improve
• Prioritize impact by simplifying and focusing on what matters most. You are customer- and patient-focused in your decision-making
• Embrace innovation and new technologies
• Thrive in a fast-paced, matrixed, agile environment. You value open communication and demonstrate a commitment to inclusion and teamwork

What you will be offered:

• An opportunity to work in one of the world's most important pharmaceutical companies
• Modern campus with plenty of green spaces and meeting areas
• Central location in Basel
• Varied job profile
• Further training opportunities through temptraining
• Working in a dynamic and motivated team

If you are interested please send your application documents addressed to Ms Marianne Buser.

Basel-Stadt Biomarker Assay Development Cellular & Functional Assays Flow Cytometry Preclinical & Clinical Bioanalysis