In this project, we aim to unravel how mRNA splicing regulates intestinal homeostasis and barrier integrity. Using gnotobiotic mouse models and patient-derived samples, we will identify metabolites affected by splicing dysregulation and determine how they influence intestinal function under both physiological and pathological conditions.

We will further explore the role of epithelial splice variants in controlling cell physiology and tumorigenic potential. To validate the clinical relevance of our findings, we will perform translational studies using human specimens.

This project offers a unique opportunity to master and integrate a wide range of experimental approaches. Methodologies will include immunological and molecular biology techniques, RNA sequencing, cell culture, histology, and bioinformatic analyses with guidance from an in-house expert. These methods will be applied to gnotobiotic and conventional mouse models as well as patient-derived colorectal cancer specimens.

This project involves extensive collaborations and cross-disciplinary scientific exchanges within the University of Bern and other scientific collaborators. The candidate will have access to state-of-the-art scientific equipment in immunology and core facilities for flow cytometry and next-generation sequencing, a germ-free and gnotobiotic mouse facility, and will receive support from our in-house Translational Research Unit (TRU) for histology and obtaining patient-derived samples.

Together, these resources and collaborations provide an exceptional framework for conducting high-impact research at the interface of RNA biology, immunology, and translational medicine.

We are seeking a highly motivated postdoctoral researcher with a PhD or MD/PhD in immunology, microbiology, or a related field. The ideal candidate will have hands-on experience with mouse models, molecular biology, cell culture techniques, RNA sequencing (single-cell and bulk), and multi-color flow cytometry, as well as a working knowledge of bioinformatic tools. Additional expertise in microbiota analysis or microbiology would be a strong asset.

The candidate should be proactive, communicative, and capable of working both independently and as part of a multidisciplinary team. Excellent command of English, strong organizational skills, and the ability to sustain collaborations across departments are essential.

This position offers a unique opportunity to engage with experts from diverse scientific backgrounds and to contribute to a rapidly advancing field at the intersection of RNA biology, immunology, and microbiome research.

Our group offers a well-funded research project within a young, dynamic, and collaborative environment. We are a close-knit team that values mutual support and scientific exchange across our diverse research projects. Bern, the capital of Switzerland, is located very close to the Swiss Alps and is well connected to many important European cities (Zurich, Paris, Milan, and Munich). The salary will be according to the standards of the University of Bern. The position is set for 2 years with the possibility of extension.

Philippe Krebs, PhD, Prof., philippe.krebs@unibe.ch, Telephone: +41 31 684 12 15

Application
If your profile matches our requirements, we look forward to receiving your application with keyword . The single PDF file should include:

• a 1-page motivation letter specifying your experience and personal attributes qualifying you for this position (please include desired start date)
• CV and copies of PhD or MD/PhD degree
• list of publications, and the names and telephone numbers/emails of three referees to Philippe Krebs.

The position will remain open until a suitable candidate is recruited.