PhD position (m/f/x) (for 3 years)
PhD position (m/f/x) (for 3 years)
PhD position (m/f/x) (for 3 years)
PhD position (m/f/x) (for 3 years)
Universitätsklinikum Erlangen
Krankenhäuser
Erlangen
Art der Beschäftigung: Teilzeit
50.000 € – 64.500 € (von XING geschätzt)Vor OrtPhD position (m/f/x) (for 3 years)
Über diesen Job
PhD position (m/f/x) (for 3 years)
Mikrobiologie
25.025 Stunden
auf 36 Monate befristet
ab 01.07.2027
Eingruppierung gemäß
TV-L
Bewerbungsfrist 15.01.2027
Prof. Dr. Christian Bogdan
Research group leader, head of the institute and spokesman of RTG2740
Tel. +49 9131 8532561
Veröffentlicht seit: 30.10.2026
Research group leader, head of the institute and spokesman of RTG2740
Tel. +49 9131 8532561
Das sind wir:
The University Hospital Erlangen, founded in 1815, is a center of state-of-the-art research and clinical medicine. More than 10,000 employees from around 50 professions carry out excellent research and care for our patients. Immunomedicine is a major research and clinical focus of the University Hospital Erlangen and the Friedrich-Alexander-University Erlangen-Nürnberg.
The Research Training Group (RTG; Graduiertenkolleg, GRK) 2740 "ImmunoMicroTope", which has started in January 2022, is a research consortium funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) and headed by Prof. Christian Bogdan. It is run by 13 outstanding research group leaders located in Erlangen and maintains close cooperations with laboratories in Regensburg and Cologne. The RTG2740 focuses on the in situ analysis of the tissue microenvironment, the micromilieu factors and the metabolites that determine the immune response against bacterial, parasitic and fungal pathogens. The overarching goal of the consortium is the characterization of the complex "immunomicrotope" during infections (Bogdan et al., Trends in Parasitology 2024 10.1016/j.pt.2024.07.013).
Your tasks:
Type 2 nitric oxide synthase (NOS2) converts the amino acid L-arginine (L-arg) and oxygen into nitric oxide, which exerts antimicrobial and immunoregulatory functions. In previous studies, Prof. Bogdan's group has shown that the NOS2 is essential for the T-helper cell 1 dependent control of intracellular pathogens, including the protozoan parasite Leishmania. In contrast, the expression of arginase 1 (Arg1) correlated with the progression of disease, pathogen persistence and immunopathology. Moreover, the group observed that the non-healing, chronic course in Leishmania mexicana infected female mice was prevented and reversed by external application of L-arg. Currently, it is unclear, whether this effect is sex-dependent and whether it is influenced by the cutaneous and/or intestinal microbiota. The project aims to adress these questions to provide new mechanistic insights into the L-arginine-based therapy of chronic leishmaniasis.
For more information, please visit www.immunomicrotope.de and www.mikrobiologie.uk-erlangen.de/en/research/research-groups/research-group-of-prof-c-bogdan/ .