The research group of Prof. Mario Zaiss ( www.zaisslab.com ( https://www.zaisslab.com/ ) ) ( http://www.zaisslab.com/ ) at the Medical Department 3 is offering a fully funded PhD position (TVL E13 65%) for 3 years to investigate the gut-CNS-joint axis in rheumatoid arthritis (RA). Chronic inflammatory diseases, such as RA, are known to activate the central nervous system (CNS), yet little is understood about how environmental factors enable the CNS to suppress peripheral inflammation. Our research has identified gut microbiota-derived histamin as a key factor in this process. We have demonstrated that low levels of this metabolite activate the enteric nervous system, increase inhibitory neurotransmitter concentrations in the spinal cord, and restore homeostatic microglia, ultimately reducing joint inflammation (doi.org/10.1101/2024.07.11.603031 ( https://doi.org/10.1101/2024.07.11.603031 ) ).

Graphical abstract ( https://www.biorxiv.org/content/biorxiv/early/2024/07/16/2024.07.11.603031/F1.large.jpg?width=800&height=600&carousel=1 )

Building on these findings, this PhD project will explore how gut-derived metabolites, modulate neuroimmune interactions to drive the resolution of arthritis.

Tasks:

• The research will employ state-of-the-art analytical techniques and provide opportunities for translational studies from preclinical models to patient applications.
• The doctoral candidate (f/m/d) will conduct experimental research on the gut-CNS-joint axis in RA, investigating the role of histamine signaling and microbiota-derived metabolites in immune regulation.
• The project will involve the use of advanced methods in molecular biology, imaging, and neuroimmunology assays , with a strong emphasis on translational research.
• The candidate (f/m/d) will work in an interdisciplinary setting , collaborating with experts in immunology, neuroscience, and microbiome research, while being expected to publish findings in peer-reviewed journals and present at international conferences

Know-How:

• Applicants (f/m/d) should have a Master’s degree (or equivalent) in Immunology, Neuroscience, Microbiology, Molecular Biology, or a related field, with a strong background in neuroimmunology, microbiome research, or inflammation
• Experience with cell culture, animal models, molecular biology, and/or imaging techniques is highly desirable.
• The ideal candidate (f/m/d) will be motivated, independent, and capable of working collaboratively , with strong written and verbal communication skills in English.

Comments:

The position offers a stimulating research environment with access to cutting-edge facilities and collaboration with leading experts in the field. Opportunities for professional development, international conferences, and career advancement are available. The start is possible immediately, preferably from 01.09.2025. To apply, candidates (f/m/d) should submit a single PDF document including a cover letter outlining research interests and motivation, a CV detailing academic background and relevant experience, transcripts and degree certificates, and contact details of two academic referees.

We offer:

• An exciting job with all the benefits of a collective agreement, including a supplementary pension from the Federal and State Pension Institution (VBL), with us as a systemically relevant employer in the public sector
• An interesting job in a motivated, open-minded team
• Thorough and qualified induction
• A comprehensive range of health promotion services
• The aim of the position is to obtain a Dr. rer. nat. degree

Contact Person:

Prof. Dr. Mario Zaiss Professor für Immuntoleranz und Autoimmunität Telefon: 09131 85-43212

Applications:

Universitätsklinikum Erlangen Medizinische Klinik 3 - Rheumatologie und Immunologie Prof. Dr. Mario Zaiss Glückstr. 4a 91054 Erlangen

Bereitgestellt in Kooperation mit der Bundesagentur für Arbeit.