Graduate Student (m/f/d) in Proteomics and BMP Signal Transduction

Graduate Student (m/f/d) in Proteomics and BMP Signal Transduction

Graduate Student (m/f/d) in Proteomics and BMP Signal Transduction

Graduate Student (m/f/d) in Proteomics and BMP Signal Transduction

German Cancer Research Center in the Helmholtz Association (DKFZ)

Pharma, Medizintechnik

Heidelberg

  • Art der Anstellung: Teilzeit
  • Vor Ort
  • Aktiv auf der Suche

Graduate Student (m/f/d) in Proteomics and BMP Signal Transduction

Ähnliche Jobs

Über diesen Job

Job Details

"Research for a life without cancer" is our mission at the German Cancer Research Center. We investigate how cancer develops, identify cancer risk factors and look for new cancer prevention strategies. We develop new methods with which tumors can be diagnosed more precisely and cancer patients can be treated more successfully. Every contribution counts – whether in research, administration or infrastructure. This is what makes our daily work so meaningful and exciting.

Starting in October 2025, the Division "Systems Biology of Signal Transduction" is seeking a

Graduate Student in Proteomics and BMP Signal Transduction

Reference number: 2025-0213

The Division "Systems Biology of Signal Transduction" headed by Prof. Dr. Ursula Klingmüller integrates advanced experimental methods with mechanistic mathematical modeling to decipher how cells respond to signals in health and disease. Understanding the fine-tuned regulation of signaling pathways is essential to uncovering disease mechanisms and identifying novel therapeutic targets, particularly in cancer and chronic liver disease.

As part of the DFG-funded FerrOs consortium, we aim to unravel the complex, organism-wide regulation of systemic iron homeostasis and its effects on bone health, using a systems biology approach. In this interdisciplinary effort, we combine mass spectrometry-based proteomics with dynamic pathway modeling to define the role of BMP signaling and iron-regulatory mechanisms in both physiological and pathological contexts.

Your Tasks

  • Investigate BMP receptor complex composition and iron-induced signal transduction in hepatocytes and hepatocellular carcinoma cells
  • Develop and apply quantitative mass spectrometry methods (global and targeted) for plasma, cell, and tissue samples to map iron-regulatory pathways
  • Integrate proteomics datasets with mechanistic mathematical models to explore regulatory dynamics of hepcidin expression and systemic iron control
  • Utilize phosphoproteomics workflows to uncover iron-dependent changes in signaling networks, with a focus on liver-bone communication
  • Collaborate closely with computational biologists, modelers, and clinicians to advance integrative models and identify sex-specific disease mechanisms
  • Contribute to publications and presentation of the results at scientific meetings
  • Your Profile
  • Master's degree in biochemistry, systems biology or a related life science discipline
  • Expertise in cell biology, signal transduction and iron metabolism (knowledge in hepatology is of advantage)
  • Expertise in mass spectrometry-based proteomics (including sample preparation, acquisition, and data interpretation)
  • Experience in handling complex omics datasets, and in applying statistical and computational tools (R, Python) for data analysis are of advantage
  • Familiarity with mathematical modeling in systems biology and pathway-level data integration is advantageous
  • Excellent teamwork and communication skills with proficiency in English and motivation to work in a collaborative, interdisciplinary environment
  • A strong scientific track record demonstrated by publications in peer-reviewed journals
  • We Offer
    • Excellent framework conditions: State-of-the-Art equipment and opportunities for international networking at the highest level
    • Access to international research networks
    • Doctoral salary with the usual social benefits
    • 30 days of vacation per year
    • Flexible working hours
    • Possibility of mobile work and part-time work
    • Family-friendly working environment
    • Sustainable travel to work: subsidized Germany job ticket
    • Unleash your full potential: targeted training and mentoring through the DKFZ International PhD Program and DKFZ Career Service
    • Our Corporate Health Management Program offers a holistic approach to your well-being

    Contact:
    Prof. Dr. Ursula Klingmüller
    Phone : +49 6221 42-4481

    The position is limited to 3 years with the possibility of prolongation.

    Application Deadline: 22.08.2025

    Are you interested?

    Then become part of the DKFZ and join us in contributing to a life without cancer!

    Applications by e-mail cannot be accepted.

    Please also note that we cannot return applications submitted by post.

    We are convinced that an innovative research and working environment thrives on the diversity of its employees. Therefore, we welcome applications from talented people, regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical ability, religion and age. People with severe disabilities are given preference if they have the same aptitude.

    Notice: We are subject to the regulations of the Infection Protection Act (IfSG). Therefore, all our employees must provide proof of immunity against measles.

    Share this job!

    Deutsches Krebsforschungszentrum | Im Neuenheimer Feld 280 | 69120 Heidelberg | www.dkfz.de

Wir benachrichtigen Dich gern über ähnliche Jobs in Heidelberg:

Ähnliche Jobs

Senior Scientist / Group Leader on Bioinformatics / Computational Biology on RNA Regulation in Disea

Mannheim

Universität Heidelberg - Medizinische Fakultät / Medical Faculty Mannheim of Heidelberg University

71.000 €95.500 €

Senior Scientist / Group Leader on Bioinformatics / Computational Biology on RNA Regulation in Disea

Mannheim

Universität Heidelberg - Medizinische Fakultät / Medical Faculty Mannheim of Heidelberg University

71.000 €95.500 €

Senior Scientist / Group Leader on Bioinformatics / Computational Biology on RNA Regulation in Disea

Mannheim

Medizinische Fakultät Mannheim

71.000 €95.500 €

Senior Scientist / Group Leader on Bioinformatics / Computational Biology on RNA Regulation in Disea

Mannheim

Medizinische Fakultät Mannheim

71.000 €95.500 €

Lead Scientist on Preclinical Disease Models for RNA-based Drug Discovery & Development (f/m/d)

Mannheim

Medizinische Fakultät Mannheim

68.500 €85.000 €

Lead Scientist on Preclinical Disease Models for RNA-based Drug Discovery & Development (f/m/d)

Mannheim

Medizinische Fakultät Mannheim

68.500 €85.000 €

PostDoc (f/m/d)

Mannheim

Medizinische Fakultät Mannheim

51.500 €63.500 €

PostDoc (f/m/d)

Mannheim

Medizinische Fakultät Mannheim

51.500 €63.500 €

Research Assistant - Next-Generation Clinically Relevant Models of Fibrosis and Wound Healing

Heidelberg

BioMed X AG

Research Assistant - Next-Generation Clinically Relevant Models of Fibrosis and Wound Healing

Heidelberg

BioMed X AG

Research Technician (f/m/d)

Heidelberg

Universität Heidelberg

42.500 €52.500 €

Research Technician (f/m/d)

Heidelberg

Universität Heidelberg

42.500 €52.500 €

HI-TAC seeks Research Group Leaders in the field of AngioCardioScience

Mannheim

Max Delbrück Center

HI-TAC seeks Research Group Leaders in the field of AngioCardioScience

Mannheim

Max Delbrück Center

PhD Student in CNV-mediated Evolution of Pediatric Brain Tumors

Heidelberg

Deutsches Krebsforschungszentrum (DKFZ)

PhD Student in CNV-mediated Evolution of Pediatric Brain Tumors

Heidelberg

Deutsches Krebsforschungszentrum (DKFZ)

Biologe (m/w/d)

Ludwigshafen am Rhein

Abax Personaldienstleistungen GmbH

45.500 €63.000 €

Biologe (m/w/d)

Ludwigshafen am Rhein

Abax Personaldienstleistungen GmbH

45.500 €63.000 €