At GSK, our mission is to improve the quality of human life by enabling people to do more, feel better, and live longer. We are a science-led global healthcare company with a special purpose: to help people do more, feel better, live longer.

We are seeking a highly motivated lab-based Tissue Omics Principal Scientist (m/f/d) with extensive expertise in cutting-edge spatial and single-cell technologies to lead the development and application of multiomics profiling approaches, pushing the boundaries of human immunology and tissue biology. The candidate will play a key role in contextualizing complex datasets by utilizing advanced analytical methods, including AI/ML tools, to generate novel insights into the mechanisms underlying human diseases.

This role requires a strong background in profiling human diseases, hands-on expertise with single-cell and spatial omics platforms (with a particular emphasis on spatial proteomics), experience in histological techniques, and exceptional analytical skills to drive data interpretation and generate meaningful insights.

Responsibilities:

• Lead experimental design and apply advanced technologies, including multiplex protein and RNA imaging, single-cell platforms, and histology readouts, to comprehensively profile patient biospecimens.
• Develop and implement automated workflows to enhance efficiency in sample processing and metadata collection.
• Effectively communicate complex analytical findings and their broader implications to diverse internal and external stakeholders through clear and impactful data presentations.
• Collaborate closely with biology, analytical and clinical teams to integrate disease profiling data into larger research initiatives, enabling actionable insights and translational outcomes.
• Drive innovation by continuously evaluating, optimizing, and adopting cutting-edge technologies to advance research capabilities.

Qualifications:

• Ph.D. in a relevant field (e.g., biology, immunology, molecular biology) with strong emphasis on human inflammatory and fibrotic diseases.
• Extensive background in profiling human diseases and knowledge of translational models and patient-derived tissue studies.
• Hands-on experience with single cell and spatial platforms (particularly spatial proteomics)
• Proficient in designing and executing experimental wet lab work, with strong analytical method implementation.
• Proven ability to lead and conduct research projects, working both independently and within a multidisciplinary team or matrix.
• Strong problem-solving, critical-thinking, organizational, and communication skills, with adaptability to a dynamic research environment.

This is an on-site role based in Heidelberg, Germany, which is fully integrated into GSK's Research and Development (R&D) and located on the campus of the European Molecular Biology Laboratory (EMBL). This diverse and stimulating environment offers a unique blend of backgrounds and expertise, fostering innovative and impactful research.

Why GSK?

• Opportunity to work in a cutting-edge scientific environment with access to state-of-the-art technologies.
• Collaborative and inclusive culture that values innovation and scientific excellence.
• Competitive compensation and benefits package.
• Commitment to professional development and career growth.

#LI-GSK

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases – to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we’re committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

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