Description:

The laboratory of Prof. Natalia Kononenko at the University of Cologne (Medical Faculty & CECAD Excellence Cluster) is seeking a highly motivated PhD candidate to investigate the role of endocytosis in Purkinje cells and how its dysfunction, leading to Purkinje cell loss, impacts brain-wide motor circuits (see Tolve et al., 2025, https://doi.org/10.1016/j.celrep.2025.115256 ).

This project is part of CRC1451 (https://www.crc1451.uni-koeln.de/) and involves advanced mouse models, rabies tracing, chemogenetics, multi-omics, super-resolution microscopy, and miniscope Ca2+ imaging. It offers an excellent opportunity to engage in cutting-edge neurobiology research.

Key Responsibilities:

• Conduct research in mouse models to investigate how inhibition of endocytosis in Purkinje cells affects information processing in the thalamo-cortical network.
• Perform experiments in cerebellar organotypic slice cultures using GCaMP6-based calcium imaging and chemogenetics.
• Perform stereotactic surgeries and use chemogenetics to manipulate brain motor circuits.
• Conduct biochemical assays, such as pull-down experiments and proteomic analyses.
• Maintain accurate lab records and clearly present findings in meetings.

Requirements:

• Master’s degree in Neuroscience, Cell Biology, or Biochemistry (with very good to excellent grades).
• Experience with techniques such as rodent models of neurodegeneration, primary cell culture, immunohistochemistry, microscopy, image analysis, and biochemical assays.
• Strong motivation to advance research in neurodegenerative diseases.
• Proficiency in English.
• Excellent organizational skills, a proactive attitude, enthusiasm, and a willingness to learn.

Our Profile:

Cologne offers a vibrant international academic environment, fostering interdisciplinary interactions with top-tier institutions such as CECAD , the Max Planck Institutes for Aging and Metabolic Research , and the University Hospital of Cologne . As a leading hub for aging research, CECAD provides an outstanding scientific network. The Kononenko lab is part of this network and offers access to state-of-the-art facilities and expertise.

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Please submit a single PDF containing the following:

1. A motivation letter.
2. A CV with contact details for 2–3 references.
3. A short (300-word) summary of a recent publication from Kononenko’s lab, including a research outlook and a proposal for future research on the topic.

Send your application to Prof. Dr. Natalia Kononenko at n.kononenko@uni-koeln.de .

For more information, please visit: