Master thesis (f/m/x) – Molecular mechanisms behind the neurodevelopmental disorder PURA syndrome
Master thesis (f/m/x) – Molecular mechanisms behind the neurodevelopmental disorder PURA syndrome
Master thesis (f/m/x) – Molecular mechanisms behind the neurodevelopmental disorder PURA syndrome
Master thesis (f/m/x) – Molecular mechanisms behind the neurodevelopmental disorder PURA syndrome
Helmholtz Zentrum München
Forschung
Oberschleißheim
- Art der Beschäftigung: Vollzeit
- Hybrid
Master thesis (f/m/x) – Molecular mechanisms behind the neurodevelopmental disorder PURA syndrome
Über diesen Job
Master thesis (f/m/x) – Molecular mechanisms behind the neurodevelopmental disorder PURA syndrome
102891
Neuherberg near Munich
At Helmholtz Munich, we develop groundbreaking solutions for a healthier society in a rapidly changing world. We believe that diverse perspectives drive innovation. Through strong partnerships, we accelerate the transfer of new ideas from the lab to real-life applications, improving lives.
We at the Institute of Structural Biology (STB) at Helmholtz Munich study the structure and function of the PURA protein. Our overall goal is to understand PURA’s cellular functions and the molecular consequences of a PURA deficiency in PURA syndrome patients. Therefore, we use genetically modified immortalized cell lines and patient-specific induced pluripotent stem cells (iPSCs). High-throughput techniques in these cells already gave us first ideas about PURA’s interactome and in which pathways PURA may play a role. These data need further validation to identify specific molecular mechanisms that cause the severe disorder. Ultimately, we want to provide information that can lead to the development of treatment strategies for PURA syndrome patients.
Interested? Join us on this crucial and challenging task for your master thesis or contact us if you want to be part of this as an intern.
For further information on the PURA Syndrome visit: https://www.purasyndrome.org/; and check out our lab: https://www.helmholtz-munich.de/en/stb/research-groups/niessing-lab
Your tasks
- Actively contribute to an ongoing research project by culturing and maintaining human neural stem cells and iPSCs
- Differentiate pluripotent stem cells into neur(on)al cells
- Plan, execute, analyze, and interpret experiments to support research activities
- Apply gene editing strategies
- Contribute to high-throughput experiments
Your profile
- Master’s student in Life Sciences (e.g. Biology, Biochemistry, Biotechnology, Molecular Biology or related fields)
- Solid theoretical background in cell biology and molecular biology; prior hands-on experience in cell culture or gene editing is advantageous
- Strong interest in experimental research and motivation to actively contribute to an ongoing scientific project
- Good written and spoken English skills
This position has a fixed term of 6 months.
Managing Director Mike Frieser:
"We believe that diversity is the key to groundbreaking research and innovative solutions. Our flexible working models and remote options create a supportive environment for balancing work and family life. For us, contributing to a healthier society in such an inspiring workplace is truly meaningful."
Interested in applying?
If you have any questions, feel free to contact Silvia Marcato, silvia.marcato@helmholtz-munich.de, who will be happy to help.
Our recruiting is decentralized - your application will be reviewed directly by the specialist department in which you could work in the future.
More information about our application process
Please send your application only via our online application tool and with the following documents:
- CV
- CV
- Cover letter
We are committed to promoting a culture of diversity and welcome applications from talented people regardless of gender, cultural background, nationality, ethnicity, sexual identity, physical abilities, religion or age. Qualified applicants with physical disabilities will be given preference.
Institute of Structural Biology