André Thomas Solioz

Periodic reviews, Q/V of Injection molding machines, tools, Assembly lines and peripherals, Consulting for Pharmaceutical Development

Furnishing of a galenical laboratory with equipment and excipients for research and development of liquid and semi-solid forms to be liquid-filled into hard capsules for contract research and internal projects Research and Development of drug delivery technologies related to GI - targeting Writing of case studies and patents based on the outcome of internal research projects Qualification of laboratory equipment (Liquid filling and banding machine, lab process plant, Titrator for Lipolysis)

Development of a mucoadhesive suspension-gel for periodontal pocket delivery from labscale to clinical phase I production scale including full documentation up to CTD Module 3 (3.2.P.1 to 3.2.P.3), Mock FDA audit without major findings passed. Preclinical development of a 2nd Generation biodegradable and sustained delivery system for treatment of the periodontal pocket. Preclinical development of semi-solid formulations for diabetic feet syndrome and actinic keratosis.

Development of special delivery systems like microemulsions, pH-modified matrix tablets and minitablets, nanosuspensions. Assessment of drug substances, special delivery systems and inhalation powders via HPLC, UPLC, microscopy, Hotstage microscopy, turbidimetry, calorimetry, XRPD, Polarimetry, NGI, DUSA. Elected as Teamspeaker of ~38 interdisciplinary teammembers, representing them to a global leadership team, organising, educating and leading the team towards self-direction and self-responsibility

Performance of Feasibilty studies and manufacturing of solutions and suspensions for DMPK/TOX studies. In-process controlls, short term stability studies and release analytics via HPLC. Contribution to two BA enhancement studies i.v. on a BCS Class II and Class IV drug comparing inclusion complexation, liposomal and liquid/solid microemulsions by developing and manufacturing the galenical formulations.

Development and Scaling up of a breast firming gel and an eye anti-fatigue roll-on from a 100g to 20kg scale. Development of a hair-straightening spray and a hair shampoo as a foam. Experience in cosmetical hair straigthening and short-timeline formulation development. In-process analytics (Viscosity, color, pH, Microscopy, spreading angle, daylight) and stability studies.

Environmental Analytics applied to assess waste water and exhaust air from a waste-water treatment plant of a production site. Performance of GC and GC-HS (Varian with FID/ECD), IC (Metrohm), wet chemistry/colorimetry, TOC/DOC (Dohrmann, Shimadzu), BSB5, Zahn-Wellens degradation. Contribution to an investigation for reducing TPC by identifying solvent recycling / exhaust air burden gaps in waste water/exhaust air. Evaluation of an IC System

Development of formulations for Inhalation devices (HFA-MDI, MDDPI). Experience in lactose coating, CU/FPF/FPD improvement, HFA emulsification. Development of an analytical procedure for estimating the FPF/FPD via laser diffraction in aerodynamic flow. In-process analytics (Microscopy, particle size, powder characteristics, pressure), stability studies. Analytical measurement of CU/FPF/FPD and water content via TI, MSLI, ACI, DUSA, Karl-Fischer titration and HPLC

Development and Scaling up of semi-solid and liquid and medical shampoos (acne, dandruff shampoos, NSAID gel and cream, Hydrating emulsifier-free lotion) from 100g to 500/3000kg scale. Elaboration of Bio-engineering techniques for measuring drug penetration through artificial membranes

Apprenticeship as Laboratory technician specialized in galenics;Development and Scaling up of semi-solid and liquid forms on OTC drugs (Eye gel, cough syrup, soft gelatine capsule filling mass, ointments, creams, lotions, vitamin and cough solutions) from a 100g to 300kg scale. Experience in taste masking; writing of SOP's, batch protocols and procedures; development of emulsifier-free creams; scaling-up (ESCO, MMU-20, MMU/FMU-100, 150, 300, Becomix); improvement of semi-solid production procedures (cooling