Cosimo Dolente

Synthesis, purification (RP-HPLC), characterization of potentially active compound. Responsibility for lab in absence of lab head for longer periods. Coaching of apprentice as 'Lehrmeister'. Proactive use of databases to support the independent design of one- or multi-step syntheses. First level support of open acces NMR and LC-MS equipment. Apply medicinal chemistry concepts to plan own lab work. Design and proposes synthesis of potentially active compounds, present own work at chemistry meeting

synthesis of reactive dyes, research and develeopment

Target identification, lead discovery, GPCR's, prodrugs, fluorine in medicinal chemistry, Proteases as targets, developing a lead, bioisosters, channles and transporters, early ADME, relevant physicochemical parameters for drug absorption BBB, drug metabolism,

Molecular targets, concept of ADME, pharmacokinetic models