Dr. Haresh Ajani

A Senior Scientist with 13+ years of pharma. industry experience, combining advanced comp. chemistry expertise with a strong track record in scientific communication, grant writing, and multidisciplinary research. My scientific expertise includes CADD, Structure and Ligand-based drug discovery, Chemoinformatics, Machine learning, and Quantum mechanics. I have applied these approaches to support drug discovery programs and solve challenging problems across different stages of pharmaceutical research.

--> Designed and discovered novel inhibitors of RBBP4 and Kinases using SBDD, LBDD, and Cheminformatics methods. -->Developed and designed Structure-Based PROTAC Design computational method for PROTAC discovery using Protein-protein docking (Rosetta, Haddock, ICM). --> Designed and screened a Proteolysis Targeting Chimeras (PROTAC) library for protein degradation targets. --> Application of Structure-Based PROTAC Design computational method for hit identification, and lead optimization of PROTAC.

--> Coordinated the design of individual projects, providing ongoing mentoring support and collaborating with medicinal chemists, biologists, and pharmacologists on drug discovery projects. --> Effectively summarised lab work, collecting, and complex quantitative data. --> Undertook regular poster presentations at both internal, national, and international meetings to a wide audience, ranging from industry professionals.

--> Published two first-author and 11 co-author peer-review articles.