Dr. Ines Eleuterio

• Team leader on Drug Discovery projects: metabolic diseases, antiviral, antibacterial and antifungal, leading the chemistry team within projects and liaise with biologists. • Line Manager of one Synthetic Chemist and mentor of a team of more junior chemists. • Design and synthesis of libraries of compounds for screening against several targets following data review and SAR delineation. • Customer services: novel synthetic routes for R&D projects involving the scale up of target molecules

Suicide Inhibitors of Sialate-Modifying Enzymes for the Investigation of their Impact on Colon Cancer Development. Synthesis of a series of sialosides as potential substrates for mammalian SOATs (sialate-O-acetyltransferase) in order to aid the analysis of SOAT specificity and activity.

Synthesis of organometallic complexes containing polyamido-amine and polyether-amido-amine ligands. Application in Ziegler-Natta Catalysis and C-H Activation. Synthesis of novel complexes of titanium to be tested as catalysts in the polymerization of alfa-olefins. X-ray determination of new crystal structures.

Synthesis of triterpenoid and steroidal glycosides important in immune responses, viral and bacterial infections, inflammation and intracellular transductions.

Preparation of dihydropyranones and derivatives.Diels-Alder reactions with furan.

Organic chemistry