Dr. Manuela López de la Paz

Phase I - IV clinical trials - Oncology Clinical site selection and activation

First-in-human, Phase I/II clinical trials and NIS (Oncology, Neurology and Rare Diseases) Site feasibility assessment, site start up, contract negotiations, remote monitoring

Clinical Research and Medical Fundamentals Regulatory Affairs and Pharmacovigilance Quality management officer (TQCert) and GMP Training Life Science process & project management, including Software Training

Development of modified neurotoxins for neurological and aesthetics indications Protein Design representative in preclinical project teams Rational design and biophysical characterization of neurotoxins Molecular Modelling software portfolio and scientific computing infrastructure Management of collaborations with academic institutions and CROs Preparation of patent applications, research publications and presentations at scientific conferences

Development of new CNS-active compounds. Modelling and design of neurotoxins. Management and scientific leadership of the Protein Modelling and Design section (methods, software and projects) Preclinical Project Manager

Design and identification of new CNS-active compounds Medicinal Chemistry and Drug Design representative in preclinical projects Supervision of PhD students

Development of computational methods for the identification of aggregation-prone regions in proteins Supervision of PhD students, postdocs and laboratory technicians Management of collaborations with academic institutions and industry

Computational de novo design of peptides and proteins NMR and CD Expert