NAVEEN GUPTA

Chemical Research & Organic Synthesis Designed and executed complex multistep synthetic strategies for advanced organic molecules, including biomimetic foldamers and substrates for asymmetric catalysis. Demonstrated expertise in modern peptide chemistry, employing N-Boc protection strategies in both liquid-phase and solid-phase synthesis (SPPS/LPPS) to build sophisticated molecular architectures. Proficient in molecule isolation and purification using multiple chromatographic techniques—silica gel, flash c

Project "H-bond donor catalysts exploiting the chiral micro environment of bioinspired helices." • Worked on the modification of the foldamers with non-proteogenic backbone and understand its influence on asymmetric catalysis. • Characterization of foldamers using LCMS and 2D NMR techniques, purification HPLC, RP-HPLC, analysis chiral HPLC.

Project "Worked on the synthesis of modified oligourea and oligourea-guanidinium hybrids for molecular recognition of anion" • Multistep synthesis of building blocks and synthesis of peptide based oligourea guanidinium foldamers • Characterization using 2D NMR methods, LCMS • Conformational studies via NMR, and crystallography • Anion binding studies via UV and CD spectroscopy (titration methods)

Project "Alpha-helicomimetic foldamers-synthesis, self-assembly and molecular recognition" • Multistep synthesis of building blocks and synthesis of foldamer for sensing of anions, study of conformation using 2D NMR techniques.