Dr. Na Zhao

Functional investigation of L-type Ca2+ channel subtypes Cav1.2 and Cav1.3 in NG2 glia with whole-cell patch-clamp techniques in brain slices; Investigation of removal of Cav1.2 and Cav1.3 in NG2 glia on neuronal activities by electrophysiology; Further investigation of roles of Cav1.2 and Cav1.3 in NG2 glia with immunohistochemistry and western blot techniques, etc. Animal behavior studies on ErasmusLadder.

Drug screening targeting ion channels using manual or automated high-throughput patch clamp techniques; Establishment of GLP electrophysiology laboratory and finally certificated by the Organization for Economic Co-operation and Development (OECD).

 Independent establishment of an electrophysiology lab;  Generation of 3 cell lines stably expressing ion channels hERG, hKv1.5, hKv4.2;  Pharmacological studies of ion channels hERG, hKv1.5, hKv4.2 and TRPV1 with patch-clamp techniques;  Commitment of hERG safety assays with patch-clamp techniques.

Establishment of heart failure animal model induced by L-thyroxine in rats; Investigation of ion channels by whole-cell patching in cadiomyocytes; Evaluation of pharmacodynamical effects on ischemia/reperfusion-induced arrhythmia model.