Dr. Nicolas Sandon

 Synthetic route design and practical synthesis of over 30 substrates for a new class of enzymes, imine reductases (IREDs), in order to determine the scope of substrate acceptance. Collaboration with the analytical department to develop achiral and chiral analytical methods for characterisation (GC, HPLC);  Valuable input in a project in clinical phase I: mechanism investigations, process improvement, synthesis of reference compounds and impurities.

Custom synthesis work from mg to kg scale: route design, practical synthesis, purification and characterisation of compounds mainly designed for the pharmaceutical industry Supervision of junior scientists and responsible for the management of lab resources Lead chemist in a Medicinal Chemistry project focused on type II diabetes: input in designing new drug candidates, SAR study, synthesis of libraries of compounds, training in cell culture and functional assays, initiation to molecular modelling

CASE Placement (during PhD) in the Medicinal Chemistry department. Team Leader: Dr. Werngard Czechtizky. Application of the methodology developed during PhD to a Medicinal Chemistry project in the pharmaceutical industry: synthesis of a library of compounds for lead optimization

Final year research Project in the department “Industrial Operations/Process Development Chemistry/Process Research”. Team Leader: Dr. A. Burgard. Improvement of the synthesis of drug candidates in order to reduce their manufacturing costs: route scouting, process optimization

Work experience in the laboratory “Organometallic and reactivity with carbon monoxide”. Team Leader: Prof. M. Röper. Improvement of the adipic acid synthesis using Pd-based complexes. Synthesis of air-sensitive phosphine ligands; Carbonylation reactions carried out in autoclaves.

“New and Efficient Strategies in Stereoselective Heterocycle Synthesis” Development of a methodology using [3+3] Cycloadditions and a Pd-TMM reagent to access chiral substituted piperidines Total synthesis of a natural product: routes towards (-)-217A a quinolizidine alkaloid

Organic Chemistry Analytical Chemistry Organometallics Biochemistry Process Engineering