Reece McCabe

The role in both departments focused on delivery of peptides/macromolecules via the gastrointestinal tract either in oral devices or solid dosage forms. Within device research I was responsible for formulation development of oral devices, characterisation of device prototypes, materials scouting and testing. Within oral formulation research I have undertaken various tableting activities within different projects. Spray drying and powder characterisation. Design of experiments, data analysis and reporting.

Responsible for formulation development, in the pharmaceutical sciences development team, of various dosage forms for first in human clinical trials. Experience of drug development including dosage forms using spray drying, wet and dry granulation, tableting, and lipid capsules. Activities included clean room manufacture and drafting of batch manufacturing records. The role also involved liaising with international clients, disseminating development data and stakeholder management.

Industrial experience for 1 year within the Interventional Vascular Innovation team developing Varithena, a low nitrogen content Micro-foam sclerosant. Placement involved fabrication of R&D samples, testing of foam quality and development of new production techniques. Designated own project which sought to validate post-manufacture treatment of a new product packaging Key achievement: Sign-off on gauge R&R experimental package for validation of new primary sterile barrier

6 month abroad stay within D-CHAB at ETH Zürich under Professor Jean-Christophe Leroux. Development of biodegradable elastomer resins for fabrication of oral devices for drug delivery

MSc Biomedical engineering (Biomaterials stream) Masters Project with Professor Molly Stevens: ’Functionalisation of extracellular vesicles for pH induced morphology change’. This project focussed on the concept of functionalising cell derived vesicles as a potential drug delivery system using pH responsive peptide conjugation.

BEng Medical materials with industrial experience 3rd year project with Professor Gleb Sukhorukov: ’Electrospinning of polymer fibres with chlorhexidine particles and layer-by- layer fabricated capsules’ This project sought to demonstrate facile encapsulation techniques to produce capsules and fibers for chlorhexidine delivery.

BEng Medical materials with industrial experience 3rd year project with Professor Gleb Sukhorukov: ’Electrospinning of polymer fibres with chlorhexidine particles and layer-by- layer fabricated capsules’ This project sought to demonstrate facile encapsulation techniques to produce capsules and fibers for chlorhexidine delivery.