Shweta Bhadri

Led protein expression studies across preclinical models for LGMD, DMD, and CMT1A gene therapies, including transcription efficiency evaluation and tissue-specific expression. Developed scalable Western blot protocols, enabling high-throughput protein analytics. Led protein expression studies in gene therapy constructs, linking molecular data to functional outcomes. Represented Sarepta as the lab delegate at an undergraduate networking event, showcasing gene therapy research and fostering academic interest.

Project: We have developed OSA murine models to assess alterations to genetic expression of Circadian genes when exposed to Intermittent hypoxic conditions in acute and chronic states. Tissue-specific assessment of transcriptomic changes in mice due to hypoxic conditions. Performed transfection assays on Mammalian cell lines (U2OS, NIH 3T3 Fibroblasts) to assess transfection efficiency, determine rhythmicity by Luminometers.