Tommaso Angelini

Develompent of new synthetic routes for the preparationpf APIs and intermediates using stereoselective hydrogenations or biocatalyzed reactions, development of analytical methods for IPCs, purity and e.e. determination. Preparation of multi-gram quantities of chiral, enantiopure molecules. Development of new green hydrogenation technologies for industrial applications. Technical and analytical support to the biocatalysis team for the design of innovative biocatalytic protocols.

Development of efficient and cost effective routes for the scale-up of APIs and intermediates. Preparation of APIs, analytical standards and impurities in multi-grams scale and support to analytical development team. Desing processes for multi-Kg production of chemical entities under GMP compliance and regulatory environment, technical and analytical support to industrial production.

Development of non-conventional synthetic methodologies for organic process with low environmental impact. Development of new continuous-flow systems combined with supported organic catalyst for efficient organic transformation with low E-factor.

Thesis: Polystyrene-Supported Bronsted and Lewis Bases as Activator for Carbon, Phosphorous and Nitrogen Pronucleophiles.