tanvi tikla

• Developed an in-vitro HHV-8 infection model in primary human cells resulting in discovery and better understanding of viral proteins associated with tumor development and spread. • Designed and optimized new assays and experimental methodologies for successful experimental protocols (angiogenesis assay, cellular toxicity and virus inhibition properties of promising drug candidates) as part of the project work package. • Fostered collaboration with interdisciplinary teams and research group at UCL to addr

• Steered projects and developed biological assays for high-throughput screening and characterisation of small drug-molecules within defined timeframe and budget by employing iterative scrum methodology. • Collaborated with strategic consultants at company Cytiva to develop a robust analytical assay for identifying small molecules and small peptide-based inhibitors with good target-binding characteristics resulting in 30% reduction in assay resource requirement and reduced the screening time by 2 months. •

Isolation and characterization of secondary metabolites from novel fungal isolates.

• Management of project timeline of two research projects and conducted experiments for Cancer invasiveness and tumor metastasis assessment. • Led cross-research group collaboration to assess the effect of their chemical derivatives on cell viability and enzymatic activity (ELISA). • Pub.: https://doi.org/10.1007/s00705-018-4060-y • Pub.: https://doi.org/10.1016/j.molstruc.2022.134151

- Assessing Indian Intellectual property rights (IPR) and Patent laws. - Drafting claims and response to patent examination reports. - Comparison of International and Indian Patent laws.

Characterisation of a novel small molecule inhibitor of Kaposi Sarcoma Herpesvirus Replication The project involves investigation and characterization of new antivirals against human herpes viruses by employing an amalgamated approach involving phenotypic screening, target based screening and stru

Publication: Nivedita Gaur, Tanvi Tikla, Rajeev Kaul (2018). Kaposi sarcoma‑associated herpes virus (KSHV) latent protein LANA modulates cellular genes associated with epithelial‑to‑mesenchymal transition. Archives of Virology. https://doi.org/10.1007/s00705-018-4060-y Master thesis: Isolation, Id