Skin T cells play a central role in protecting the body, but their dysregulated activation drives chronic inflammatory skin disease. Current treatments suppress inflammation, yet rarely provide long-term cure. To develop curative therapies, we need to understand the upstream mechanisms that sustain inflammation, such as the interleukin-18 (IL-18) pathway.
Recent findings suggest that IL-18 plays a crucial role in atopic dermatitis (AD). Therefore, we aim to address:

• IL-18-responsive immune cells across blood and lesional AD skin
• The inflammatory cytokine milieu shaped by IL-18
• The neutralization of IL-18 as a therapeutic strategy for AD

You will work with primary human T cells from PBMCs and skin, using flow cytometry, transcriptomic profiling (single-cell RNA sequencing), multiplex cytokine assays, and human skin explant models to clarify IL-18's role and therapeutic potential in AD.

For further information, please contact:
Prof. Dr. med. Dr. phil. Christoph Schlapbach, Professor of Department of Dermatology
E-mail christoph.schlapbach@insel.ch

Your application should include:

• Curriculum vitae with a brief description of laboratory experience

We look forward to receiving your complete