Dr. Alexander Kuhl

Prometheus Innovent is specialized on Managing Change with focus on Product Design & Development, i.e. business processes, meeting customer demands applying System Thinking and Agile & Lean methodologies. We assure a structured approach to innovation and establishes in your Change Management and Product Development effort the customer view as starting point to any consideration. This paradigm will assure that your teams emphasize with customer needs to build great products that solve meaningful problems.

Roche is one of the very few MNCs which achieved to establish a fully integrated global development hub in China: In my role as Functional Manager Study Management I am responsible to manage a team of Gobal Studies Leaders, Managers and Associates in the TAs Immunology, Infectional Diseases and Ophthalmology, Neuroscience and Metabolics to deliver global and regional studies

Established a regionally cooperating Clinical Project Management organization by transforming a clinical research organization into a project management organization through implementing structured work processes and best practice for study management. Improved the quality and timeliness of clinical study conduct measured through predifined KPIs. Fostered work performance through definition and implemention of leadership, communication and proficiency competencies. Managed overall 52 studies and 38 FTEs

- Heading Global Project and supervising Clinical Study Teams - Leading global development projects from preclinical into clinical stages by initiating and directing clinical development studies in phase I, IIb and III - Managing an overall development budget of 145 million € - Established global KOL network for hypertension program - Created Asia specific diabetes development projects - Training and mentoring a team of project manager

- Leading and co-chairing cross-functional global project and brand teams in the cardiovascular area, e.g. Adalat, Aspirin and Glucobay - Establishing and implementing brand and life cycle management strategies - Created global development projects applying Fixed Dose Combination and innovative formulation strategies for marketed products by establishing agreement on target product profiles, development plans and business cases, e.g. Adalat FDC Candesartan franchise and development programs

- Responsible for the regulatory life cycle management activities of ethical and biological products - Created regulatory strategies and established successful alignment with Health Authorities - Aligned regulatory activities for re-launch of Aspirin i.v. in Germany - 15 NDA accomplished with focus on multinational & European registration procedures for biological products, e.g. Gamunex

- Responsible for the lead optimization of HTS structures to candidates presently under development, e.g. selective Mineral Corticoid Receptor Antagonist

- Coordinating the lead optimization activities of three laboratory units within strategic projects for cardiovascular programs

- Project work in medicinal chemistry for the therapeutic areas Bacteriology and Cardiovascular Diseases - Responsibility for up to four co-workers

Natural Product Chemistry Organometalic Chemistry Coordination Chemistry

Naturstoffchemie Organische Chemie Technische Chemie