Dr. Ann-Christine Gradtke

I built up an immunological lab. This included introduction and guidance of technical personal, organisation of the move of laboratory material, setting up experimental systems and writing standard operating procedures. Thereby I also established a retroviral transduction protocol for murine bone marrow. Furthermore I was responsible for a new doctoral student. I also had teaching duties in the Biochemistry practical course for medical students.

During my doctoral studies I investigated the role of the intramembrane protease SPPL2a and its substrate CD74 (li, invariant chain) in development and function of dendritic cells. My model were bone marrow-derived dendritic cells and macrophages, which I generated from different knock out mouse lines, I took care of. I also worked with primary and immortalised B cells. I supervised a laboratory assistant trainee, a bachelor student and several research assistants.